RENATO ARAÚJO PRATES

RENATO ARAÚJO PRATES

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Low Intensity laser therapy in patients with burning mouth syndrome: a randomized, placebo-controlled study
2016 - SUGAYA, NORBERTO N.; SILVA, ERICA F.P. da; KATO, ILKA T.; PRATES, RENATO; GALLO, CAMILA de B.; PELLEGRINI, VIVIAN D.
The aim of this study was to assess the effectiveness of low intensity laser therapy in patients with Burning Mouth Syndrome (BMS). Thirty BMS subjects were randomized into two groups -Laser (LG) and Placebo (CG). Seven patients dropped out, leaving 13 patients in LG and 10 patients in CG. Each patient received 4 irradiations (laser or placebo) twice a week, for two consecutive weeks (blinded to the type of irradiation received). Infrared laser (AsGaAI) irradiations were applied to the affected mucosa in scanning mode, wavelength of 790 nm, output power of 20 mW and fluence of 6 J/cm(2). A visual analogue scale (VAS) was used to assess the therapeutic effect before and after each irradiation, and at all the control time periods: 7, 14, 30, 60 and 90 days after the last irradiation. One researcher delivered irradiation and another recorded the results. Both researchers were blinded, the first to the results, and the second to the type of radiation applied. The results were categorized according to the percentage of symptom level variation, and showed a statistically better response in LG in only two categories of the control checkpoints (p=0.02; Fisher's Exact Test). According to the protocol used in this study, low intensity laser therapy is as beneficial to patients with BMS as placebo treatment, indicating a great emotional component of involvement in BMS symptomatology. Nevertheless, there were positive results in some statistical analyses, thus encouraging further research in BMS laser therapy with other irradiation parameters.
Antimicrobial photodynamic inactivation inhibits Candida albicans virulence factors and reduces In vivo pathogenicity
2013 - KATO, ILKA T.; PRATES, RENATO A.; SABINO, CAETANO P.; FUCHS, BETH B.; TEGOS, GEORGE P.; MYLONAKIS, ELEFTHERIOS; HAMBLIN, MICHAEL R.; RIBEIRO, MARTHA S.
Effect of virulence factors on the photodynamic inactivation of Cryptococcus neoformans
2013 - PRATES, RENATO A.; FUCHS, BETH B.; MIZUMO, KAZUE; NAQVI, QURAT; KATO, ILKA T.; RIBEIRO, MARTHA S.; MYLONAKIS, ELEFTHERIOS; TEGOS, GEORGE P.; HAMBLIN, MICHAEL R.
Opportunistic fungal pathogens may cause an array of superficial infections or serious invasive infections, especially in immunocompromised patients. Cryptococcus neoformans is a pathogen causing cryptococcosis in HIV/AIDS patients, but treatment is limited due to the relative lack of potent antifungal agents. Photodynamic inactivation (PDI) uses the combination of non-toxic dyes called photosensitizers and harmless visible light, which produces singlet oxygen and other reactive oxygen species that produce cell inactivation and death. We report the use of five structurally unrelated photosensitizers (methylene blue, Rose Bengal, selenium derivative of a Nile blue dye, a cationic fullerene and a conjugate between poly-L-lysine and chlorin(e6)) combined with appropriate wavelengths of light to inactivate C. neoformans. Mutants lacking capsule and laccase, and culture conditions that favoured melanin production were used to probe the mechanisms of PDI and the effect of virulence factors. The presence of cell wall, laccase and melanin tended to protect against PDI, but the choice of the appropriate photosensitizers and dosimetry was able to overcome this resistance.
Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans
2011 - PRATES, RENATO A.; KATO, ILKA T.; RIBEIRO, MARTHA S.; TEGOS, GEORGE P.; HAMBLIN, MICHAEL R.
Low-level laser therapy in burning mouth syndrome patients
2010 - KATO, ILKA T.; PELLEGRINI, VIVIAN D.; PRATES, RENATO A.; RIBEIRO, MARTHA S.; WETTER, NIKLAUS U.; SUGAYA, NORBERTO N.
Objective: The aim of this study was to investigate the effect of low-level laser therapy (LLLT) on the treatment of burning mouth syndrome (BMS). In addition, the laser effect was compared on the different affected oral sites. Materials and Methods: Eleven subjects with a total of 25 sites (tongue, lower lip, upper lip, and palate) affected by a burning sensation were selected. The affected areas were irradiated once a week for three consecutive weeks with an infrared laser (l ¼ 790 nm). The probe was kept in contact with the tissue, and the mucosal surface was scanned during the irradiation. The exposure time was calculated based on the fluence of 6 J/cm2 , the output power of 120 mW, and the area to be treated. Burning intensity was recorded through a visual analog scale before and after the treatment and at the 6-week follow-up. The percentage of the improvement in symptoms was also obtained. Results: Burning intensity at the end of the laser therapy was statistically lower than at the beginning ( p < 0.01). Patients reported an 80.4% reduction in the intensity of symptoms after laser treatment. There was no statistical difference between the end of the treatment and the 6-week follow-up, except for the tongue site. Conclusion: Under the investigated parameters, infrared LLLT proved to be a valuable alternative for BMS treatment, providing a significant and lasting reduction in symptoms.
Histomorphometric and microbial assessment of photodynamic therapy as an adjuvant treatment for periodontilis: A short-term evaluation of inflammatory periodontal conditions and bacterial reduction in a rat model
2011 - PRATES, RENATO A.; YAMADA JUNIOR, AECIO M.; SUZUKI, LUIS C.; FRANÇA, CRISTIANE M.; CAI, SILVANA; MAYER, MARCIA P.A.; RIBEIRO, ADRIANA C.; RIBEIRO, MARTHA S.