Stability of the neomycin antibiotic in irradiated polymeric biomaterials

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dc.contributor.authorZAFALON, ANGELICA T.pt_BR
dc.contributor.authorSANTOS, VINICIUS J. dospt_BR
dc.contributor.authorLUGAO, ADEMAR B.pt_BR
dc.contributor.authorRANGARI, VIJAYApt_BR
dc.contributor.authorTEMESGEN, SAMUELpt_BR
dc.contributor.authorPARRA, DUCLERC F.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2019-07-25T13:26:54Z
dc.date.available2019-07-25T13:26:54Z
dc.date.issued2018pt_BR
dc.description.abstractHydrogels can be produced by gamma radiation at 25 kGy. Free radicals from water radiolysis are responsible by crosslinking of the polymer and chain scission. On the other hand, gamma radiation can lead degradation of pharmaceuticals. Neomycin loaded hydrogel was prepared and the stabity of neomycin was evaluaded. Excipents were used to measure radioprotector potencial each one. HPLC-MS/MS method and thermal analysis were used to analysis effect of gamma irradiation in neomycin stability. PEG was a excipients in hydrogel formulation and showed to be a radioprotector. Neomycin was stable under gamma radiation when loaded in hydrogel.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipIDCAPES: 88881.134341/2016-01pt_BR
dc.description.sponsorshipIDFAPESP: 16/19254-0pt_BR
dc.format.extent49-57pt_BR
dc.identifier.citationZAFALON, ANGELICA T.; SANTOS, VINICIUS J. dos; LUGAO, ADEMAR B.; RANGARI, VIJAYA; TEMESGEN, SAMUEL; PARRA, DUCLERC F. Stability of the neomycin antibiotic in irradiated polymeric biomaterials. <b>European Journal of Biomedical and Pharmaceutical Sciences</b>, v. 5, n. 7, p. 49-57, 2018. Disponível em: http://repositorio.ipen.br/handle/123456789/29951.
dc.identifier.fasciculo7pt_BR
dc.identifier.issn2349-8870pt_BR
dc.identifier.orcid0000-0002-6481-0155pt_BR
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7626-880X
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.percentilfiSem Percentil
dc.identifier.percentilfiCiteScoreSem Percentil CiteScore
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29951
dc.identifier.vol5pt_BR
dc.relation.ispartofEuropean Journal of Biomedical and Pharmaceutical Sciencespt_BR
dc.rightsopenAccesspt_BR
dc.subjectstability
dc.subjectneomycin
dc.subjectantibiotics
dc.subjecthydrogels
dc.subjectgamma radiation
dc.subjectdecomposition
dc.subjectradiation effects
dc.subjectthermal analysis
dc.titleStability of the neomycin antibiotic in irradiated polymeric biomaterialspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorDUCLERC FERNANDES PARRA
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorVINICIUS JUVINO DOS SANTOS
ipen.autorANGELICA TAMIÃO ZAFALON
ipen.codigoautor562
ipen.codigoautor339
ipen.codigoautor14044
ipen.codigoautor6419
ipen.contributor.ipenauthorDUCLERC FERNANDES PARRA
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorVINICIUS JUVINO DOS SANTOS
ipen.contributor.ipenauthorANGELICA TAMIÃO ZAFALON
ipen.date.recebimento19-07
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.fiCiteScoreSem CiteScore
ipen.identifier.ipendoc25734pt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublication67996d86-0a59-4ba2-8d38-facaa14e26c3
relation.isAuthorOfPublication99ac24c5-2ae1-465a-a6f2-40b4d9af6af7
relation.isAuthorOfPublicatione7446613-4b8b-42e0-a53b-077674c2c830
relation.isAuthorOfPublication49d823d7-3167-4065-8db0-9ed6915062cc
relation.isAuthorOfPublication.latestForDiscovery49d823d7-3167-4065-8db0-9ed6915062cc
sigepi.autor.atividadePARRA, DUCLERC F.:562:740:Npt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadeSANTOS, VINICIUS J. dos:14044:750:Npt_BR
sigepi.autor.atividadeZAFALON, ANGELICA T.:6419:740:Spt_BR

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