Micro-homogeneity evaluation of a bovine kidney candidate reference material
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2017
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60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS
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Resumo
Assessing the homogeneity is one of the critical steps in the process of preparing
and certifying a reference material (RM). One of the parameters that must be estimated
is the minimum sample intake for which the material remains homogeneous,
that is, that the concentration and uncertainty values present in the certificate continue
to be valid.
In general, the Certified Reference Materials (CRM) producers establish a minimum
sample intake of 200mg, estimated in a conservative way, and useful for classical
analytical methods that use sample masses greater than this value. From the appearance
of analytical techniques that use less sample quantities, such as ICP, it became
increasingly important to be able to clearly estimate which is the real minimum sample
intake of the RM.
The present work describes the micro-homogeneity study of a bovine kidney candidate
reference material.
In order to obtain an estimate of the minimum sample intake amount, assays
were performed to determine the Kurfurst constant (HE), a parameter used for this
purpose by several authors. Measurements should be carried out using a method
that allows analyzing a low sample quantity, with good accuracy and low uncertainty.
In this work was used Instrumental Neutron Activation Analysis, INAA, a reference
technique for the evaluation of the degree of homogeneity of RM.
Ten sub-samples of approximately 1mg were analyzed to evaluate the HE for the
elements Cl, K, Mn and Na, and ten sub-samples of approximately 2mg to evaluate
the HE for Co, Fe, Mg, Se and Zn. Results obtained for HE in all the analyzed
elements were satisfactory. The estimated minimum sample intake was between
1mg and 50mg, depending of the element.
Como referenciar
CASTRO, L.; MOREIRA, E.G.; VASCONCELLOS, M.B.A. Micro-homogeneity evaluation of a bovine kidney candidate reference material. In: 60 YEARS OF IEA-R1: INTERNATIONAL WORKSHOP ON UTILIZATION OF RESEARCH REACTORS, November 28 - December 01, 2017, São Paulo, SP. Abstract... São Paulo, SP: Instituto de Pesquisas Energéticas e Nucleares, 2017. p. 34-34. Disponível em: http://repositorio.ipen.br/handle/123456789/28730. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.