In vitro assessment of the composition and microhardness of the hard tissues of oral cavity submitted to gamma irradiation
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International Journal of Cancer Research & Therapy
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Introduction: Clinical radiotherapy is one of the most important techniques for the treatment of malignant lesions
in head and neck; however, exposure to ionizing radiation may lead to both systemic and local complications,
immediately and after this treatment, where the main issue is the xerostomia and its consequent oral mucositis.
Regarding late complications produced by radiation, decay of radiation and osteoradionecrosis, both dosedependent
lesions, showed a high level of incidence in recent decades and it would be difficult to manage, although
patients referred after treatment’s completion and under the influence of local factors.
Methodology: Then, This study evaluated the effect of ionizing radiation from gamma source onto samples of
enamel, root dentin and jawbone samples undergone to the same absorbed dose / dose rate that those in patients
with head and neck cancer. The non-irradiated and irradiated samples were analyzed by microhardness surface
analysis; scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR).
Results and discussion: Microhardness data were analyzed statistically with a confidence level of 95% (p value
<0.05%), using parametric Student’s t-test for related averages and ANOVA statistical test, finding a statistically
significant result (p = 0.00) to all four groups samples.
Conclusion: It was observed a high deleterious and statistical significant effect of gamma radiation on hard tissues
from oral cavity, regarding to physical, compositional and morphological properties.
Como referenciar
PAREDES, WILBER E.B.; ARI, SANDRA F.; GERALDO, AUREA B.C.; ANDRADE, DELVONEI A. de. In vitro assessment of the composition and microhardness of the hard tissues of oral cavity submitted to gamma irradiation. International Journal of Cancer Research & Therapy, v. 2, n. 1, p. 1-12, 2017. Disponível em: http://repositorio.ipen.br/handle/123456789/27812. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.