Cytotogenic and dosimetric effects of sup(131)I in patients with differentiated thyroid carcinoma: comparison between stimulation with rhTSH and thyroid hormone withdrawal treatments

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dc.contributor.authorSILVA, MARCIA A. da
dc.contributor.authorVALGODE, FLAVIA G.S.
dc.contributor.authorGONZALEZ, JULIA A.
dc.contributor.authorYORIYAZ, HELIO
dc.contributor.authorGUIMARAES, MARIA I.C.C.
dc.contributor.authorRIBELA, MARIA T.C.P.
dc.contributor.authorBUCHPIGUEL, CARLOS A.
dc.contributor.authorBARTOLINI, PAOLO
dc.contributor.authorOKAZAKI, KAYO
dc.coverageInternacionalpt_BR
dc.date.accessioned2016-08-03T12:52:26Z
dc.date.available2016-08-03T12:52:26Z
dc.date.issued2016pt_BR
dc.description.abstractA study directed to the cytogenetic and dosimetric aspects of radionuclides of medical interest is very valuable, both for an accurate evaluation of the dose received by the patients, and consequently of the genetic damage, and for the optimization of therapeutic strategies. Cytogenetic and dosimetric effects of 131I in lymphocytes of thyroidectomized differentiated thyroid cancer (DTC) patients were evaluated through chromosome aberration (CA) technique: Euthyroid patients submitted to recombinant human thyroid-stimulating hormone (rhTSH) therapy (group A) were compared with hypothyroid patients left without levothyroxine treatment (group B). CA analysis was carried out prior to and 24 h, 1 week, 1 month and 1 year after radioiodine administration (4995–7030 MBq) in both groups. An activity–response curve of 131I (0.074–0.740 MBq/mL) was elaborated, comparing dicentric chromosomes in vivo and in vitro in order to estimate the absorbed dose through Monte Carlo simulations. In general, radioiodine therapy induced a higher total CA rate in hypothyroid patients as compared to euthyroid patients. The frequencies of dicentrics obtained in DTC patients 24 h after treatment were equivalent to those induced in vitro (0.2903 ± 0.1005 MBq/mL in group A and 0.2391 ± 0.1019 MBq/mL in group B), corresponding to absorbed doses of 0.65 ± 0.23 Gy and 0.53 ± 0.23 Gy, respectively. The effect on lymphocytes of internal radiation induced by 131I therapy is minimal when based on the frequencies of CA 1 year after the treatment, maintaining a higher quality of life for DTC patients receiving rhTSHaided therapy.
dc.format.extent317-328pt_BR
dc.identifier.citationSILVA, MARCIA A. da; VALGODE, FLAVIA G.S.; GONZALEZ, JULIA A.; YORIYAZ, HELIO; GUIMARAES, MARIA I.C.C.; RIBELA, MARIA T.C.P.; BUCHPIGUEL, CARLOS A.; BARTOLINI, PAOLO; OKAZAKI, KAYO. Cytotogenic and dosimetric effects of sup(131)I in patients with differentiated thyroid carcinoma: comparison between stimulation with rhTSH and thyroid hormone withdrawal treatments. <b>Radiation on Environmental Biophysics</b>, v. 55, p. 317-328, 2016. DOI: <a href="https://dx.doi.org/10.1007/s00411-016-0646-5">10.1007/s00411-016-0646-5</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/26527.
dc.identifier.doi10.1007/s00411-016-0646-5
dc.identifier.issn0301-634Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4023-236X
dc.identifier.percentilfi60.56
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/26527
dc.identifier.vol55pt_BR
dc.relation.ispartofRadiation on Environmental Biophysicspt_BR
dc.rightsopenAccesspt_BR
dc.subjectiodine 131
dc.subjectchromosomal aberrations
dc.subjecttsh
dc.subjectthyroid hormones
dc.subjectdosimetry
dc.subjectthyroid
dc.subjectcarcinomas
dc.subjectclinical trials
dc.subjectcomparative evaluations
dc.subjecttherapy
dc.titleCytotogenic and dosimetric effects of sup(131)I in patients with differentiated thyroid carcinoma: comparison between stimulation with rhTSH and thyroid hormone withdrawal treatmentspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorHELIO YORIYAZ
ipen.autorKAYO OKAZAKI
ipen.autorPAOLO BARTOLINI
ipen.autorMARIA TERESA DE CARVALHO PINTO RIBELA
ipen.autorFLAVIA GOMES SILVA VALGODE
ipen.autorMARCIA AUGUSTA DA SILVA
ipen.codigoautor80
ipen.codigoautor1220
ipen.codigoautor1503
ipen.codigoautor1197
ipen.codigoautor3927
ipen.codigoautor2589
ipen.contributor.ipenauthorHELIO YORIYAZ
ipen.contributor.ipenauthorKAYO OKAZAKI
ipen.contributor.ipenauthorPAOLO BARTOLINI
ipen.contributor.ipenauthorMARIA TERESA DE CARVALHO PINTO RIBELA
ipen.contributor.ipenauthorFLAVIA GOMES SILVA VALGODE
ipen.contributor.ipenauthorMARCIA AUGUSTA DA SILVA
ipen.date.recebimento16-08pt_BR
ipen.identifier.fi2.398pt_BR
ipen.identifier.ipendoc22433pt_BR
ipen.identifier.ods3
ipen.range.fi1.500 - 2.999
ipen.range.percentilfi50.00 - 74.99
ipen.type.genreArtigo
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relation.isAuthorOfPublication.latestForDiscoveryae3998e8-9d0e-4bf0-b40f-92a4234f7463
sigepi.autor.atividadeSILVA, MARCIA A. DA:2589:-1:S
sigepi.autor.atividadeVALGODE, FLAVIA G.S.:3927:810:N
sigepi.autor.atividadeYORIYAZ, HELIO:80:420:N
sigepi.autor.atividadeRIBELA, MARIA T.C.P.:1197:-1:N
sigepi.autor.atividadeBARTOLINI, PAOLO:1503:810:N
sigepi.autor.atividadeOKAZAKI, KAYO:1220:-1:N
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