Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction
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2020
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Radiation Physics and Chemistry
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Radiolytic synthesis and phytochemical-driven gold reduction for the generation of nanoparticles are successful
examples of Green Chemistry applied for nanomaterials. The present work compares these two green approaches
focusing on hydrodynamic size, stability over time, optical properties and toxicity in NIH 3T3 (ATCC® CRL-
1658™) cells and Danio rerio (Zebra Fish). The radiolytic synthesis was performed by mixing 1 mM NaAuCl4;
polyvinyl pyrrolidone 0.5%, AgNO3 6×10−5 M, propan-2-ol 0.2 M and acetone 0.06 M, followed by irradiation
at 15 kGy (5 kGy h−1, 60Co source). The EGCG-functionalized nanoparticles were synthesized by mixing 1.6 mM
of Au with 0.8 mM of EGCG in phosphate buffer (10 mM) for 2 h. Both methods yield the formation of gold
nanoparticles featuring plasmon resonance bands at 520–530 nm, polydispersity above 0.3 was relevant only for
the radiolytic protocol. Regarding stability over time, after 30 days, the nanoparticles synthesized radiolytically
presented no relevant size changes, while some aggregation was observed for the EGCG-particles. The same
nanoparticles demonstrated a lack of stability in high ionic strength medium. Slight toxicity was observed for the
EGCG-nanoparticles in Danio rerio, with an IC50 calculated as 40.49%, while no IC50 was established within the
concentration range of radiolysis-AuNPs used in this study. In conclusion, both green methods generated nanoparticles
with good control of size and optical properties, especially via reduction by EGCG. However, the
stability and toxicity results were found to be more promising for the radiolytically synthesized gold nanoparticles.
Como referenciar
FREITAS, LUCAS F. de; CRUZ, CASSIA P.C. da; CAVALCANTE, ADRIANA K.; BATISTA, JORGE G. dos S.; VARCA, GUSTAVO H.C.; MATHOR, MONICA B.; LUGAO, ADEMAR B. Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction. Radiation Physics and Chemistry, v. 174, p. 1-9, 2020. DOI: 10.1016/j.radphyschem.2020.108959. Disponível em: http://repositorio.ipen.br/handle/123456789/31427. Acesso em: 03 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.