Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties
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Medical Mycology
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Resumo
Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the
thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries
of Latin America and can cause a high-burden fungal infection with significant morbidity
and mortality. The peptide P10, which demonstrates immune protection against
experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. The radiolabeling
was conducted to trace the pharmacokinetics of the molecule in principal
organs and tissues. This was achieved with high radiochemical purity. Biodistribution
and scintigraphic imaging showed fast blood clearance that was mainly renal; however,
hepatobiliar excretion was also, withmarked uptake in cervical lymph nodes. This profile
may be useful for the development of a prophylactic drug or vaccine for patients exposed
to PCM.
Como referenciar
FAINTUCH, BLUMA L.; OLIVEIRA, ERICA A.; MUNOZ, JULIAN E.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P. Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties. Medical Mycology, v. 52, n. 5, p. 1-5, 2014. DOI: 10.1093/mmy/myu024. Disponível em: http://repositorio.ipen.br/handle/123456789/27706. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.