Strengthening collaborations at the Biology‑Physics interface
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Biophysical Reviews
Exportar
Resumo
The unbridled use of antimicrobial drugs over the last decades contributed to the global dissemination of drug-resistant
pathogens and increasing rates of life-threatening infections for which limited therapeutic options are available. Currently, the
search for safe, fast, and efective therapeutic strategies to combat infectious diseases is a worldwide demand. Antimicrobial
photodynamic therapy (APDT) rises as a promising therapeutic approach against a wide range of pathogenic microorganisms. APDT combines light, a photosensitizing drug (PS), and oxygen to kill microorganisms by oxidative stress. Since the
APDT feld involves branches of biology and physics, the strengthening of interdisciplinary collaborations under the aegis
of biophysics is welcome. Given this scenario, Brazil is one of the global leaders in the production of APDT science. In this
review, we provide detailed reports of APDT studies published by the Laboratory of Optical Therapy (IPEN-CNEN), Group
of Biomedical Nanotechnology (UFPE), and collaborators over the last 10 years. We present an integrated perspective of
APDT from basic research to clinical practice and highlight its promising use, encouraging its adoption as an efective and
safe technology to tackle important pathogens. We cover the use of methylene blue (MB) or Zn(II) porphyrins as PSs to
kill bacteria, fungi, parasites, and pathogenic algae in laboratory assays. We describe the impact of MB-APDT in Dentistry
and Veterinary Medicine to treat diferent infectious diseases. We also point out future directions combining APDT and
nanotechnology. We hope this review motivates further APDT studies providing intuitive, vivid, and insightful information
for the readers.
Como referenciar
CABRAL, FERNANDA V.; SOUZA, TIAGO H. dos S.; SALLERA, FABIO P.; FONTES, ADRIANA; RIBEIRO, MARTHA S. Strengthening collaborations at the Biology‑Physics interface: trends in antimicrobial photodynamic therapy. Biophysical Reviews, v. 15, n. 4, p. 685-697, 2023. DOI: 10.1007/s12551-023-01066-5. Disponível em: http://repositorio.ipen.br/handle/123456789/34213. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.