Possible molds for a new brachytherapy source for spinal and intracranial cancer
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2023
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BRAZIL MRS MEETING, 21st
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Central Nervous System (CNS) cancer is the 18th most incident cancer in the world,
according to the World Health Organization (WHO), and in 2020, in Brazil, it represented
2.5% of all new cancer deaths [1]. Brachytherapy is a type of radiotherapy that positions the
radioactive source close to (or in contact with) the tumor. Thus, the targeted region receives
most of the dose, protecting the healthy tissues adjacent to the tumor. A promising
radioactive source for use in brachytherapy for the treatment of CNS cancer is
phosphorus-32 in a polymeric substrate. This source has been prominent as a minimally
invasive treatment for craniopharyngiomas and in the treatment of metastatic bone diseases
in general [2]. To produce such a source, it is necessary to search for possible molds that
can conform the polymeric material into the desired format. Several tests were carried out
to determine the best mold for the radioactive source manufacture. Different materials were
tested to observe if the mold material would react with the source's components, silicone
rubber mixed with orthophosphoric acid. In order to be considered a possible mold, the
mixture should cure; if the cure did not concretize, the mold would be descarted. It was
concluded that polystyrene (PS) obtained the best result, due to the ease of unmold after the
resin curing process.
Como referenciar
TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ROSERO, WILMMER A.A.; VIEIRA, JOSE M.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M. Possible molds for a new brachytherapy source for spinal and intracranial cancer. In: BRAZIL MRS MEETING, 21st, October 1-5, 2023, Maceió, AL. Abstract... São Carlos, SP: Aptor Software, 2023. p. 461-461. Disponível em: http://repositorio.ipen.br/handle/123456789/34558. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.