Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model
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Journal of Biophotonics
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This study evaluated the biological effects of low-level laser
therapy (LLLT) on bone remodeling, tooth displacement
and root resorption, occurred during the orthodontic
tooth movement. Upper first molars of a total of sixtyeight
male rats were subjected to orthodontic tooth movement
and euthanized on days 3, 6, 9, 14 and 21 days and
divided as negative control, control and LLLT group.
Tooth displacement and histomorphometric analysis were
performed in all animals; scanning electron microscopy
analysis was done on days 3, 6 and 9, as well as the immunohistochemistry
analysis of RANKL/OPG and TRAP
markers. Volumetric changes in alveolar bone were analyzed
using MicroCT images on days 14 and 21. LLLT influenced
bone resorption by increasing the number of
TRAP-positive osteoclasts and the RANKL expression at
the compression side. This resulted in less alveolar bone
and hyalinization areas on days 6, 9 and 14. LLLT also
induced less bone volume and density, facilitating significant
acceleration of tooth movement and potential reduction
in root resorption besides stimulating bone formation
at the tension side by enhancing OPG expression, increasing
trabecular thickness and bone volume on day 21. Taken
together, our results indicate that LLLT can stimulate
bone remodeling reducing root resorption in a rat model.
Como referenciar
SUZUKI, SELLY S.; GARCEZ, AGUINALDO S.; SUZUKI, HIDEO; ERVOLINO, EDILSON; MOON, WON; RIBEIRO, MARTHA S. Low-level laser therapy stimulates bone metabolism and inhibits root resorption during tooth movement in a rodent model. Journal of Biophotonics, v. 9, n. 11-12, p. 1222–1235, 2016. DOI: 10.1002/jbio.201600016. Disponível em: http://repositorio.ipen.br/handle/123456789/27011. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.