Methylene blue-mediated photodynamic therapy on cutaneous leishmaniasis
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2019
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INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th
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Cutaneous leishmaniasis (CL) is a neglected disease, which promotes destructive lesions. Difficulties in treatment are related to resistance and toxicity. Methylene blue-mediated photodynamic therapy (MB-PDT) has emerged as a promising treatment considering low cost and no reports about resistance. We evaluated MB-PDT on Leishmania amazonensis in vitro and in vivo using a red LED at different fluences. Our results demonstrated that the best fluence in vitro was not effective in vivo, and a higher dose was necessary to provide better responses in mice. This study reinforces the idea that a well-planned protocol is necessary for a successful MB-PDT on CL.
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CABRAL, FERNANDA V.; RIBEIRO, MARTHA S. Methylene blue-mediated photodynamic therapy on cutaneous leishmaniasis: an in vitro and in vivo study. In: INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th, June 28 - July 4, 2019, Cambridge, Massachusetts, USA. Abstract... Disponível em: http://repositorio.ipen.br/handle/123456789/30951. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.