Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomography
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Journal of Biomedical Optics
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Photodynamic therapy (PDT) has become a promising alternative for treatment of skin lesions such as
squamous cell carcinoma. We propose a method to monitor the effects of PDT in a noninvasive way by using
the optical attenuation coefficient (OAC) calculated from optical coherence tomography (OCT) images. We
conducted a study on mice with chemically induced neoplastic lesions and performed PDT on these lesions
using homemade photosensitizers. The response of neoplastic lesions to therapy was monitored using, at
the same time, macroscopic clinical visualization, histopathological analysis, OCT imaging, and OCT-based
attenuation coefficient measurement. Results with all four modalities demonstrated a positive response to treatment. The attenuation coefficient was found to be 1.4 higher in skin lesions than in healthy tissue and it
decreased after therapy. This study shows that the OAC is a potential tool to noninvasively assess the evolution
of skin neoplastic lesions with time after treatment.
Como referenciar
GOULART, VIVIANE P.; SANTOS, MOISES O. dos; LATRIVE, ANNE; FREITAS, ANDERSON Z.; CORREA, LUCIANA; ZEZELL, DENISE M. Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomography. Journal of Biomedical Optics, v. 20, n. 5, p. 051007-1 - 051007-7, 2015. DOI: 10.1117/1.JBO.20.5.051007. Disponível em: http://repositorio.ipen.br/handle/123456789/25404. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.