Synthesis and application of the MCM-41 and SBA-15 as matrices for in vitro efavirenz release study

Abstract

The mesoporous materials in particular the Mobil Composition of Matter No. 41 (MCM-41) and Santa Barbara Amorphous-15 (SBA-15) are considered promising as devices for controlled drug release, because of properties such as hexagonal arrangement, high surface area and non-cytotoxic properties. The materials were synthesized under hydrothermal method and efavirenz (EFZ) was used for testing of controlled release. The material obtained was ordered and had high surface area even after of the incorporation of the drug. The test of the release was made with capsules and the reading was made by UV/Vis with the time interval during two hours to evaluation the efficiency of the dissolution profile of the drug.