GPX1 Pro198Leu polymorphism and GSTM1 deletion do not affect selenium and mercury status in mildly exposed Amazonian women in an urban population
Carregando...
Data
Data de publicação
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Science of the Total Environment
ODS
Exportar
Resumo
Mercury is potent toxicant element, but its toxicity can be reduced by forming a complex with selenium for safe
excretion. Considering the impact of mercury exposure in the Amazon region and the possible interaction between
these two elements,we aimed to assess the effects of Pro198Leu polymorphism to GPX1 and GSTM1 deletion,
on mercury levels in a population from Porto Velho, an urban locality in the Brazilian Amazon region. Two
hundredwomen fromthe capital city of Rondônia statewere recruited for this study with 149 deemed suitable to
participate. We assessed dietary intake using 24-hour recall. Selenium levels in plasma and erythrocytes were
measured using hydride generation quartz tube atomic absorption spectroscopy and total hair mercury using
cold vapor atomic absorption spectrometry. Oxidative stress parameters (GPx activity, oxygen radical absorbency
capacity [ORAC] and malondialdehyde [MDA]) were also analyzed. All participants were genotyped for
Pro198Leu polymorphism and GSTM1 deletion.We observed that this population presented high prevalence of
selenium deficiency, and also low levels of mercury, likely due to food habits that did not include seleniumrich
food sources or significant consumption of fish (mercury biomagnifiers) regularly. Univariate statistical analysis
showed that Pro198Leu and GSTM1 genotypes did not affect seleniumand mercury levels in this population.
Como referenciar
ROCHA, ARIANA V.; CARDOSO, BARBARA R.; ZAVARIZE, BRUNA; ALMONDES, KALUCE; BORDON, ISABELLA; HARE, DOMINIC J.; FAVARO, DEBORAH I.T.; COZZOLINO, SILVIA M.F. GPX1 Pro198Leu polymorphism and GSTM1 deletion do not affect selenium and mercury status in mildly exposed Amazonian women in an urban population. Science of the Total Environment, v. 571, p. 801-808, 2016. DOI: 10.1016/j.scitotenv.2016.07.054. Disponível em: http://repositorio.ipen.br/handle/123456789/27189. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.