Optical coherence tomography for blood glucose monitoring in vitro through spatial and temporal approaches
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Journal of Biomedical Optics
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As diabetes causes millions of deaths worldwide every year, new methods for blood glucose monitoring
are in demand. Noninvasive approaches may increase patient adherence to treatment while reducing
costs, and optical coherence tomography (OCT) may be a feasible alternative to current invasive diagnostics.
This study presents two methods for blood sugar monitoring with OCT in vitro. The first, based on spatial statistics,
exploits changes in the light total attenuation coefficient caused by different concentrations of glucose in
the sample using a 930-nm commercial OCT system. The second, based on temporal analysis, calculates
differences in the decorrelation time of the speckle pattern in the OCT signal due to blood viscosity variations
with the addition of glucose with data acquired by a custom built Swept Source 1325-nm OCT system. Samples
consisted of heparinized mouse blood, phosphate buffer saline, and glucose. Additionally, further samples were
prepared by diluting mouse blood with isotonic saline solution to verify the effect of higher multiple scattering
components on the ability of the methods to differentiate glucose levels. Our results suggest a direct relationship
between glucose concentration and both decorrelation rate and attenuation coefficient, with our systems being
able to detect changes of 65 mg∕dL in glucose concentration.
Como referenciar
PRETTO, LUCAS R. de; YOSHIMURA, TANIA M.; RIBEIRO, MARTHA S.; FREITAS, ANDERSON Z. de. Optical coherence tomography for blood glucose monitoring in vitro through spatial and temporal approaches. Journal of Biomedical Optics, v. 21, n. 8, p. 086007-1 - 086007-7, 2016. DOI: 10.1117/1.JBO.21.8.086007. Disponível em: http://repositorio.ipen.br/handle/123456789/27006. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.