Machine learning methods for micro-FTIR imaging classification of tumors and more
Carregando...
Data
Data de publicação
2022
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 45.
Exportar
Resumo
Fourier transform infrared micro-spectroscopy imaging (µ-FTIR) has emerged as one of the important tools for studying and characterizing biological materials. It is a label-free technique, relatively simple, reproducible, non-destructive to the tissue and provides accurate results. The vast amount of data and fundamental information obtained from hyperspectral images may not be readily evident. Classical statistics, through its models (parametric and non-parametric) is not able to support the increasing volume of generated data and its high dimensionality. The multivariate analysis of data presents many advantages to be explored, capable of extracting information from the infrared spectra, which go beyond the one-dimensional space, revealing characteristics or properties in the data collected from the samples. The spectral data analysis pipeline, such as the pre-processing steps and the modeling that the Biophotonics Laboratory at Ipen – Cnen, is using in the analysis of biological tissues will be discussed. Results will be presented for body fluids in the disease diagnosis, as well as thyroid, skin and breast tumors, in particular the expression of estrogen and progesterone receptors through tumor biopsies of human cell lines inoculated in mice. µ-FTIR images were collected from histological sections, and six machine learning models were applied and evaluated. The Xtreme gradient boost and Linear Discriminant Analysis showed the best accuracy results, indicating that they are potential models for breast cancer classification tasks.
Como referenciar
ZEZELL, DENISE M. Machine learning methods for micro-FTIR imaging classification of tumors and more. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 45., 10-14 de abril, 2022, São Paulo, SP. Resumo... São Paulo, SP: Sociedade Brasileira de Física, 2022. Disponível em: http://repositorio.ipen.br/handle/123456789/33319. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.