Genotoxic evaluation of [DOTA, Tyrsup(3)]octreotate labelled with sup(131)I and sup(177)Lu in human peripheral lymphocytes in vitro by micronucleus assay

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dc.contributor.authorSUZUKI, MIRIAM F.pt_BR
dc.contributor.authorSILVA, MARCIA A. dapt_BR
dc.contributor.authorCALDEIRA FILHO, JOSE de S.pt_BR
dc.contributor.authorCOLTURATO, MARIA T.pt_BR
dc.contributor.authorARAUJO, ELAINE B. dept_BR
dc.contributor.authorBARTOLINI, PAOLOpt_BR
dc.contributor.authorOKAZAKI, KAYOpt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:45:33Zpt_BR
dc.date.accessioned2014-07-30T11:50:12Z
dc.date.available2014-07-15T13:45:33Zpt_BR
dc.date.available2014-07-30T11:50:12Z
dc.date.issued2007pt_BR
dc.description.abstract[DOTA, Tyr3 ]octreotate has been used for cancer diagnosis and therapy because of its high affinity to somatostatin subtype receptors sstr2 and sstr5. The aim of this study was to evaluate the cytogenetic effect of radio-labelled [DOTA, Tyr3 ]octreotate in blood cells in vitro, using the cytokinesis-block micronucleus assay. Blood samples of healthy donors were exposed to different activities of [DOTA, Tyr3 ]octreotate labelled with 131I (n = 3) and 177Lu (n = 3), where radioactive concentration ranged from 600 to 5600 kBq/mL. The cells were cultivated according to criteria adopted by the IAEA (Vienna). The results showed a positive correlation between radioactive concentrations (X) and the frequency of binucleated cells with micronuclei (Y) (P < 0.05). The linear equations were similar: for the 131I labelled, Y = (1.634 ± 0.236) + (0.912 ± 0.137) 10–3 X and for the 177Lu labelled, Y = (1.715 ± 0.342) + (0.743 ± 0.135) 10–3 X.
dc.format.extent161-168pt_BR
dc.identifier.citationSUZUKI, MIRIAM F.; SILVA, MARCIA A. da; CALDEIRA FILHO, JOSE de S.; COLTURATO, MARIA T.; ARAUJO, ELAINE B. de; BARTOLINI, PAOLO; OKAZAKI, KAYO. Genotoxic evaluation of [DOTA, Tyrsup(3)]octreotate labelled with sup(131)I and sup(177)Lu in human peripheral lymphocytes in vitro by micronucleus assay. <b>International Journal of Low Radiation</b>, v. 4, n. 2, p. 161-168, 2007. DOI: <a href="https://dx.doi.org/10.1504/IJLR.2007.015440">10.1504/IJLR.2007.015440</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/5203.
dc.identifier.doi10.1504/IJLR.2007.015440
dc.identifier.fasciculo2pt_BR
dc.identifier.issn1477-6545pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/5203pt_BR
dc.identifier.vol4pt_BR
dc.relation.ispartofInternational Journal of Low Radiationpt_BR
dc.rightsclosedAccessen
dc.subjectdose-response relationshipspt_BR
dc.subjectexperimental datapt_BR
dc.subjectgenetic radiation effectspt_BR
dc.subjectin vitropt_BR
dc.subjectiodine 131pt_BR
dc.subjectlabelled compoundspt_BR
dc.subjectlutetium 177pt_BR
dc.subjectlymphocytespt_BR
dc.subjectneoplasmspt_BR
dc.subjectsomatostatinpt_BR
dc.subjecttoxicitypt_BR
dc.titleGenotoxic evaluation of [DOTA, Tyrsup(3)]octreotate labelled with sup(131)I and sup(177)Lu in human peripheral lymphocytes in vitro by micronucleus assaypt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorMARIA TEREZA COLTURATO
ipen.autorKAYO OKAZAKI
ipen.autorPAOLO BARTOLINI
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorJOSE DE SOUZA CALDEIRA FILHO
ipen.autorMARCIA AUGUSTA DA SILVA
ipen.autorMIRIAM FUSSAE SUZUKI
ipen.codigoautor434
ipen.codigoautor1220
ipen.codigoautor1503
ipen.codigoautor664
ipen.codigoautor1155
ipen.codigoautor2589
ipen.codigoautor557
ipen.contributor.ipenauthorMARIA TEREZA COLTURATO
ipen.contributor.ipenauthorKAYO OKAZAKI
ipen.contributor.ipenauthorPAOLO BARTOLINI
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorJOSE DE SOUZA CALDEIRA FILHO
ipen.contributor.ipenauthorMARCIA AUGUSTA DA SILVA
ipen.contributor.ipenauthorMIRIAM FUSSAE SUZUKI
ipen.date.recebimento08-03pt_BR
ipen.identifier.fiSem F.I.pt_BR
ipen.identifier.ipendoc12287pt_BR
ipen.type.genreArtigo
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sigepi.autor.atividadeSUZUKI, MIRIAM F.:557:18:Spt_BR
sigepi.autor.atividadeSILVA, MARCIA A. DA:2589:-1:Npt_BR
sigepi.autor.atividadeCALDEIRA FILHO, JOSE de S.:1155:12:Npt_BR
sigepi.autor.atividadeCOLTURATO, MARIA T.:434:12:Npt_BR
sigepi.autor.atividadeARAUJO, ELAINE B. DE:664:12:Npt_BR
sigepi.autor.atividadeBARTOLINI, PAOLO:1503:18:Npt_BR
sigepi.autor.atividadeOKAZAKI, KAYO:1220:18:Npt_BR
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