Genotoxic evaluation of [DOTA, Tyrsup(3)]octreotate labelled with sup(131)I and sup(177)Lu in human peripheral lymphocytes in vitro by micronucleus assay
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International Journal of Low Radiation
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[DOTA, Tyr3
]octreotate has been used for cancer diagnosis and
therapy because of its high affinity to somatostatin subtype receptors sstr2
and sstr5. The aim of this study was to evaluate the cytogenetic effect of
radio-labelled [DOTA, Tyr3
]octreotate in blood cells in vitro, using the
cytokinesis-block micronucleus assay. Blood samples of healthy donors were
exposed to different activities of [DOTA, Tyr3
]octreotate labelled with 131I
(n = 3) and 177Lu (n = 3), where radioactive concentration ranged from 600 to
5600 kBq/mL. The cells were cultivated according to criteria adopted by the
IAEA (Vienna). The results showed a positive correlation between radioactive
concentrations (X) and the frequency of binucleated cells with micronuclei (Y)
(P < 0.05). The linear equations were similar: for the 131I labelled, Y = (1.634
± 0.236) + (0.912 ± 0.137) 10–3 X and for the 177Lu labelled, Y = (1.715
± 0.342) + (0.743 ± 0.135) 10–3 X.
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SUZUKI, MIRIAM F.; SILVA, MARCIA A. da; CALDEIRA FILHO, JOSE de S.; COLTURATO, MARIA T.; ARAUJO, ELAINE B. de; BARTOLINI, PAOLO; OKAZAKI, KAYO. Genotoxic evaluation of [DOTA, Tyrsup(3)]octreotate labelled with sup(131)I and sup(177)Lu in human peripheral lymphocytes in vitro by micronucleus assay. International Journal of Low Radiation, v. 4, n. 2, p. 161-168, 2007. DOI: 10.1504/IJLR.2007.015440. Disponível em: http://repositorio.ipen.br/handle/123456789/5203. Acesso em: 20 Mar 2026.
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