Identifying the molecular fingerprint of beta-lactams via Raman/SERS Spectroscopy using unconventional nanoparticles for antimicrobial stewardship
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Antibiotics
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Abstract: Background/Objectives: Beta-lactam antibiotics, derived from penicillin, are the most used
class of antimicrobials used for treating bacterial infections. Over the years, microorganisms have
developed resistance mechanisms capable of preventing the effect of these drugs. This condition
has been a significant public health concern for the 21st century, especially after predictions that
antimicrobial resistance could lead to 10 million deaths annually by 2050. The challenge of developing
new antimicrobials brings with it the need to ensure the efficacy of existing ones, hence the importance
of developing fast and low-cost monitoring techniques. Methods: In this study, we present an
alternative based on nanophotonics using Surface-Enhanced Raman Spectroscopy (SERS) mediated
by nanoparticles for the detection of antimicrobials, with emphasis on some beta-lactam antibiotics
commonly prescribed in cases of critically ill patients. It is a sensitive and accurate technique
for drug monitoring, allowing for rapid and specific detection of its molecular signatures. This
approach is crucial to address the challenge of antimicrobial resistance and ensure the therapeutic
efficacy of existing treatments. Results: Our experiments demonstrate the possibility of identifying
spectra with characteristic vibrations (fingerprints) of these antimicrobials via SERS. Conclusions:
Our results point to new strategies for molecular monitoring of drugs by optical techniques using
unconventional nanoparticles.
Como referenciar
ANJOS, VINICIUS P.; MARANGONI, CAROLINE G.P. da S.; NADAS, RAFAEL; MACHADO, THIAGO N.; KRUL, DAMARIS; RODRIGUES, LUIZA S.; DALLA-COSTA, LIBERA M.; SCHREINER, WIDO H.; ZEZELL, DENISE M.; BEZERRA JUNIOR, ARANDI G.; GOES, RAFAEL E. de. Identifying the molecular fingerprint of beta-lactams via Raman/SERS Spectroscopy using unconventional nanoparticles for antimicrobial stewardship. Antibiotics, v. 13, n. 12, p. 1-18, 2024. DOI: 10.3390/antibiotics13121157. Disponível em: https://repositorio.ipen.br/handle/123456789/49002. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.