Study of blood porphyrin spectral profile for diagnosis of chronic renal failure

Página do item simplificado
dc.contributor.authorTRISTAO, VIVIAN R.pt_BR
dc.contributor.authorCARVALHO, FERNANDO F. dept_BR
dc.contributor.authorGOMES, CINTHIA Z.pt_BR
dc.contributor.authorMIRANDA, ADRIANA R.pt_BR
dc.contributor.authorVEQUI-SUPLICY, CINTIA C.pt_BR
dc.contributor.authorLAMY, MARIA T.pt_BR
dc.contributor.authorSCHOR, NESTORpt_BR
dc.contributor.authorBELLINI, MARIA H.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2014-07-15T13:38:56Zpt_BR
dc.date.accessioned2014-07-30T11:49:16Z
dc.date.available2014-07-15T13:38:56Zpt_BR
dc.date.available2014-07-30T11:49:16Z
dc.date.issued2010pt_BR
dc.description.abstractThe progression to end-stage renal failure is independent of the initial pathogenic mechanism. Metabolic acidosis is a common consequence of chronic renal failure that results from inadequate ammonium excretion and decreased tubular bicarbonate reabsorption. Protoporphyrin IX (PpIX) is the immediate metabolic precursor of the heme molecule. The purpose of this study was to evaluate the levels of erythrocytes protoporphyrin IX at an animal model during progressive renal disease. A total of 36 eightweek-old male Wistar rats were divided into six groups: Normal, 4 and 8 weeks after 5/6 nephrectomy (NX). Renal function was evaluated by creatinine clearance and plasma creatinine levels. The autofluorescence of erythrocytes porphyrin of healthy and NX rats was analyzed using fluorescence spectroscopy. Emission spectra were obtained by exciting the samples at 405 nm. Significant differences between normal and NX rats autofluorescence shape occurred in the 600–700 nm spectral region. A correlation was observed between emission band intensity at 635 nm and progression of renal disease.
dc.format.extent665-669pt_BR
dc.identifier.citationTRISTAO, VIVIAN R.; CARVALHO, FERNANDO F. de; GOMES, CINTHIA Z.; MIRANDA, ADRIANA R.; VEQUI-SUPLICY, CINTIA C.; LAMY, MARIA T.; SCHOR, NESTOR; BELLINI, MARIA H. Study of blood porphyrin spectral profile for diagnosis of chronic renal failure. <b>Journal of Fluorescence</b>, v. 20, n. 3, p. 665-669, 2010. DOI: <a href="https://dx.doi.org/10.1007/s10895-010-0600-x">10.1007/s10895-010-0600-x</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/4606.
dc.identifier.doi10.1007/s10895-010-0600-x
dc.identifier.fasciculo3pt_BR
dc.identifier.issn1053-0509pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2852-6189
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/4606pt_BR
dc.identifier.vol20pt_BR
dc.relation.ispartofJournal of Fluorescencept_BR
dc.rightsopenAccessen
dc.subjectkidneyspt_BR
dc.subjectdiseasespt_BR
dc.subjecterythrocytespt_BR
dc.subjectporphyrinspt_BR
dc.subjectanimal cellspt_BR
dc.subjectfluorescence spectroscopypt_BR
dc.titleStudy of blood porphyrin spectral profile for diagnosis of chronic renal failurept_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorCINTHIA ZANINI GOMES
ipen.autorADRIANA REGINA MIRANDA
ipen.autorMARIA HELENA BELLINI MARUMO
ipen.codigoautor8696
ipen.codigoautor8695
ipen.codigoautor1242
ipen.contributor.ipenauthorCINTHIA ZANINI GOMES
ipen.contributor.ipenauthorADRIANA REGINA MIRANDA
ipen.contributor.ipenauthorMARIA HELENA BELLINI MARUMO
ipen.date.recebimento10-12pt_BR
ipen.identifier.fi1.966pt_BR
ipen.identifier.ipendoc16097pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi1.500 - 2.999
ipen.type.genreArtigo
relation.isAuthorOfPublication3dcc73ca-1a8f-429a-8fae-9bfae241067c
relation.isAuthorOfPublication4b23af94-9cd1-43ab-ae0f-a010c2e0102f
relation.isAuthorOfPublication6a450cbf-91b1-4386-b4a8-7304afac99cc
relation.isAuthorOfPublication.latestForDiscovery3dcc73ca-1a8f-429a-8fae-9bfae241067c
sigepi.autor.atividadeGOMES, CINTHIA Z.:8696:820:Npt_BR
sigepi.autor.atividadeMIRANDA, ADRIANA R.:8695:820:Npt_BR
sigepi.autor.atividadeBELLINI, MARIA H.:1242:820:Npt_BR
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
16097.pdf
Tamanho:
158.86 KB
Formato:
Adobe Portable Document Format
Baixar
Coleções
Periódicos