Assessment of bone dose response using ATR-FTIR spectroscopy
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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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The health care application of ionizing radiation has expanded worldwide during the last several decades.
While the health impacts of ionizing radiation improved patient care, inaccurate handling of radiation
technology is more prone to potential health risks. Therefore, the present study characterizes the bone
dose response using bovine femurs from a slaughterhouse. The gamma irradiation was designed into
low-doses (0.002, 0.004 and 0.007 kGy) and high-doses (1, 10, 15, 25, 35, 50 and 60 kGy), all samples
received independent doses. The combination of FTIR spectroscopy and PLS-DA allows the detection of
differences in the control group and the ionizing dose, as well as distinguishing between high and low
radiation doses. In this way, our findings contribute to future studies of the dose response to track ionizing
radiation effects on biological systems.
Como referenciar
CASTRO, PEDRO A.A. de; DIAS, DERLY A.; DEL-VALLE, MATHEUS; VELOSO, MARCELO N.; SOMESSARI, ELIZABETH S.R.; ZEZELL, DENISE M. Assessment of bone dose response using ATR-FTIR spectroscopy: a potential method for biodosimetry. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 273, p. 1-7, 2022. DOI: 10.1016/j.saa.2022.120900. Disponível em: http://repositorio.ipen.br/handle/123456789/33215. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.