Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis
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Current Radiopharmaceuticals
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Background and Objective: Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists.
Methods: We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium-99m. Two different sites of the biomolecule were selected for chelator attachment.
Results: HYNIC-beta Ala chelator attached to serine (C-terminus) of exendin, was associated with higher tumor uptake than to aspartate (N-terminus).
Conclusion: The chelator position in the biomolecule influenced receptor uptake.
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FAINTUCH, BLUMA L.; SEO, DANIELE; OLIVEIRA, ERICA A. de; TARGINO, ROSELAINE C.; MORO, ANA M. Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis. Current Radiopharmaceuticals, v. 10, n. 1, p. 65-72, 2017. DOI: 10.2174/1874471010666170126143636. Disponível em: http://repositorio.ipen.br/handle/123456789/27705. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.