Synthesis of PLGA using a Csub(3)-synmmetric Zr (IV) amine tris(phenolate) alkoxide initiator and the effects of gamma radiation on its properties
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In this paper, we report the preparation and characterisation of
poly(lactic-co-glycolic) acid (PLGA) using a C3-symmetric Zr (IV) amine
tris(phenolate) alkoxide initiator. Although the zirconium alkoxide initiator is
slower than the most commonly used Sn(Oct)2, relatively high molecular weights
were obtained at a temperature of 130 C, for a monomer to initiator ratio of 1000/1
(24 h) and 5000/1 (48 h). The degree of racemisation also depends on the initiator
used. The reactions performed with the zirconium initiator showed a higher degree
of racemisation when compared to those performed with Sn(Oct)2. A slight increase
in the racemisation with time was also observed. The effects of gamma radiation on
PLGA were also studied. Doses commonly applied to sterilise materials for
biomedical applications were employed—10, 18, 25 and 50 kGy. The molecular
weight of all samples irradiated decreased in a dose-dependent fashion—up to 56 %
loss for 10 kGy and 72 % for 50 kGy—but were less pronounced for higher doses.
Changes in thermal properties, such as melting point, glass transition temperature
and enthalpy of crystallisation and fusion, were also observed after irradiation.
Como referenciar
PELEIAS JUNIOR, FERNANDO dos S.; JONES, MATHEW D.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.; MOREIRA JUNIOR, PAULO F. Synthesis of PLGA using a Csub(3)-synmmetric Zr (IV) amine tris(phenolate) alkoxide initiator and the effects of gamma radiation on its properties. Polymer Bulletin, v. 74, p. 91-105, 2017. Disponível em: http://repositorio.ipen.br/handle/123456789/26535. Acesso em: 30 Jun 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.