Magnetic core mesoporous silica nanoparticles doped with dacarbazine and labelled with 99mTc for early and differential detection of metastatic melanoma by single photon emission computed tomography
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Artificial Cells, Nanomedicine, and Biotechnology
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Cancer is responsible for more than 12% of all causes of death in the world, with an annual death rate
of more than 7 million people. In this scenario melanoma is one of the most aggressive ones with serious
limitation in early detection and therapy. In this direction we developed, characterized and tested
in vivo a new drug delivery system based on magnetic core-mesoporous silica nanoparticle that has
been doped with dacarbazine and labelled with technetium 99 m to be used as nano-imaging agent
(nanoradiopharmaceutical) for early and differential diagnosis and melanoma by single photon emission
computed tomography. The results demonstrated the ability of the magnetic core-mesoporous silica to
be efficiently (>98%) doped with dacarbazine and also efficiently labelled with 99mTc (technetium
99 m) (>99%). The in vivo test, using inducted mice with melanoma, demonstrated the EPR effect of
the magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled with technetium
99 metastable when injected intratumorally and the possibility to be used as systemic injection
too. In both cases, magnetic core-mesoporous silica nanoparticles doped with dacarbazine and labelled
with technetium 99 metastable showed to be a reliable and efficient nano-imaging agent for
melanoma.
Como referenciar
PORTILHO, FILIPE L.; HELAL-NETO, EDWARD; CABEZAS, SANTIAGO S.; PINTO, SUYENE R.; SANTOS, SOFIA N. dos; POZZO, LORENA; SANCENON, FELIX; MARTINEZ-MANEZ, RAMON; SANTOS-OLIVEIRA, RALPH. Magnetic core mesoporous silica nanoparticles doped with dacarbazine and labelled with 99mTc for early and differential detection of metastatic melanoma by single photon emission computed tomography. Artificial Cells, Nanomedicine, and Biotechnology, v. 46, p. S1080–S1087, 2018. S1. DOI: 10.1080/21691401.2018.1443941. Disponível em: http://repositorio.ipen.br/handle/123456789/29947. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.