Environmental tobacco smoke during the early postnatal period of mice interferes with brain 18F-FDG uptake from infancy to early adulthood
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Frontiers in Neuroscience
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Exposure to environmental tobacco smoke (ETS) is associated with high morbidity and
mortality, mainly in childhood. Our aim was to evaluate the effects of postnatal ETS
exposure in the brain 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake of mice by
positron emission tomography (PET) neuroimaging in a longitudinal study. C57BL/6J
mice were exposed to ETS that was generated from 3R4F cigarettes from postnatal
day 3 (P3) to P14. PET analyses were performed in male and female mice during
infancy (P15), adolescence (P35), and adulthood (P65). We observed that ETS exposure
decreased 18F-FDG uptake in the whole brain, both left and right hemispheres, and
frontal cortex in both male and female infant mice, while female infant mice exposed
to ETS showed decreased 18F-FDG uptake in the cerebellum. In addition, all mice
showed reduced 18F-FDG uptake in infancy, compared to adulthood in all analyzed
VOIs. In adulthood, ETS exposure during the early postnatal period decreased brain 18FFDG
uptake in adult male mice in the cortex, striatum, hippocampus, cingulate cortex,
and thalamus when compared to control group. ETS induced an increase in 18F-FDG
uptake in adult female mice when compared to control group in the brainstem and
cingulate cortex. Moreover, male ETS-exposed animals showed decreased 18F-FDG
uptake when compared to female ETS-exposed in the whole brain, brainstem, cortex,
left amygdala, striatum, hippocampus, cingulate cortex, basal forebrain and septum,
thalamus, hypothalamus, and midbrain. The present study shows that several brain
regions are vulnerable to ETS exposure during the early postnatal period and these effects on 18F-FDG uptake are observed even a long time after the last exposure.
This study corroborates our previous findings, strengthening the idea that exposure to
tobacco smoke in a critical period interferes with brain development of mice from late
infancy to early adulthood.
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TORRES, LARISSA H.; REAL, CAROLINE C.; TURATO, WALTER M.; SPELTA, LÍDIA W.; DURÃO, ANA C.C. dos S.; ANDRIOLI, TATIANA C.; POZZO, LORENA; SQUAIR, PETERSON L.; PISTIS, MARCO; FARIA, DANIELE de P.; MARCOURAKIS, TANIA. Environmental tobacco smoke during the early postnatal period of mice interferes with brain 18F-FDG uptake from infancy to early adulthood: a longitudinal study. Frontiers in Neuroscience, v. 14, p. 1-11, 2020. DOI: 10.3389/fnins.2020.00005. Disponível em: http://repositorio.ipen.br/handle/123456789/31363. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.