Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models

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dc.contributor.authorPUJATTI, PRISCILLA B.
dc.contributor.authorFOSTER, JULIE M.
dc.contributor.authorFINUCANE, CIARA
dc.contributor.authorHUDSON, CHANTELLE D.
dc.contributor.authorBURNET, JEROME C.
dc.contributor.authorPASQUALOTO, KERLY F.M.
dc.contributor.authorMENGATTI, JAIR
dc.contributor.authorMATHER, STEPHEN J.
dc.contributor.authorARAUJO, ELAINE B. de
dc.contributor.authorSOSABOWSKI, JANE K.
dc.coverageInternacionalpt_BR
dc.date.accessioned2015-01-06T13:07:30Z
dc.date.available2015-01-06T13:07:30Z
dc.date.issued2015pt_BR
dc.description.abstractWe evaluated and compared a new bombesin analog [Tyr–Gly5, Nle14]-BBN(6–14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were radiolabeled with high radiochemical purity and specific activity. In vitro assays on T-47D, LNCaP and PC3 cells showed that the affinity of peptides is similar and a higher binding and internalization of DOTApeptide to PC-3 cells was observed. Both peptides could
dc.format.extent91-101pt_BR
dc.identifier.citationPUJATTI, PRISCILLA B.; FOSTER, JULIE M.; FINUCANE, CIARA; HUDSON, CHANTELLE D.; BURNET, JEROME C.; PASQUALOTO, KERLY F.M.; MENGATTI, JAIR; MATHER, STEPHEN J.; ARAUJO, ELAINE B. de; SOSABOWSKI, JANE K. Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models. <b>Applied Radiation and Isotopes</b>, v. 96, p. 91-101, 2015. DOI: <a href="https://dx.doi.org/10.1016/j.apradiso.2014.11.006">10.1016/j.apradiso.2014.11.006</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/23226.
dc.identifier.doi10.1016/j.apradiso.2014.11.006
dc.identifier.issn0969-8043pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.percentilfi35.56
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/23226
dc.identifier.vol96pt_BR
dc.relation.ispartofApplied Radiation and Isotopespt_BR
dc.rightsopenAccesspt_BR
dc.subjectradiopharmaceuticals
dc.subjectdtpa
dc.subjectlabelled compounds
dc.subjectindium 111
dc.subjectneoplasms
dc.subjectpeptides
dc.subjectimpurities
dc.subjectcomparative evaluations
dc.titleEvaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor modelspt_BR
dc.typeArtigo de periódicopt_BR
dspace.entity.typePublication
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorJAIR MENGATTI
ipen.autorPRISCILLA BRUNELLI PUJATTI
ipen.codigoautor664
ipen.codigoautor1498
ipen.codigoautor6795
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorJAIR MENGATTI
ipen.contributor.ipenauthorPRISCILLA BRUNELLI PUJATTI
ipen.date.recebimento14-12pt_BR
ipen.identifier.fi1.136pt_BR
ipen.identifier.ipendoc20274pt_BR
ipen.identifier.ods3
ipen.range.fi0.001 - 1.499
ipen.range.percentilfi25.00 - 49.99
ipen.type.genreArtigo
relation.isAuthorOfPublicationca74886d-6974-47a8-9308-c4cc39bb6e35
relation.isAuthorOfPublication4722b83e-1d23-488f-b497-6a72d3048679
relation.isAuthorOfPublication9ea38f67-2c4c-445a-b2f8-4f05edf0ff29
relation.isAuthorOfPublication.latestForDiscovery9ea38f67-2c4c-445a-b2f8-4f05edf0ff29
sigepi.autor.atividadePUJATTI, PRISCILLA B.:6795:-1:S
sigepi.autor.atividadeMENGATTI, JAIR:1498:110:N
sigepi.autor.atividadeARAUJO, ELAINE B. DE:664:110:N

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