Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models
Carregando...
Data
Data de publicação
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Applied Radiation and Isotopes
ODS
Exportar
Resumo
We evaluated and compared a new bombesin analog [Tyr–Gly5, Nle14]-BBN(6–14) conjugated to DOTA or
DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were
radiolabeled with high radiochemical purity and specific activity. In vitro assays on T-47D, LNCaP and PC3 cells showed that the affinity of peptides is similar and a higher binding and internalization of DOTApeptide to PC-3 cells was observed. Both peptides could
Como referenciar
PUJATTI, PRISCILLA B.; FOSTER, JULIE M.; FINUCANE, CIARA; HUDSON, CHANTELLE D.; BURNET, JEROME C.; PASQUALOTO, KERLY F.M.; MENGATTI, JAIR; MATHER, STEPHEN J.; ARAUJO, ELAINE B. de; SOSABOWSKI, JANE K. Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models. Applied Radiation and Isotopes, v. 96, p. 91-101, 2015. DOI: 10.1016/j.apradiso.2014.11.006. Disponível em: http://repositorio.ipen.br/handle/123456789/23226. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.