Pluronic F-127 hydrogels containing copper oxide nanoparticles and a nitric oxide donor to treat skin cancer
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Melanoma is a serious and aggressive type of skin cancer with growing incidence, and
it is the leading cause of death among those affected by this disease. Although surgical resection
has been employed as a first-line treatment for the early stages of the tumor, noninvasive topical
treatments might represent an alternative option. However, they can be irritating to the skin and
result in undesirable side effects. In this context, the potential of topical polymeric hydrogels has been
investigated for biomedical applications to overcome current limitations. Due to their biocompatible
properties, hydrogels have been considered ideal candidates to improve local therapy and promote
wound repair. Moreover, drug combinations incorporated into the polymeric-based matrix have
emerged as a promising approach to improve the efficacy of cancer therapy, making them suitable
vehicles for drug delivery. In this work, we demonstrate the synthesis and characterization of Pluronic
F-127 hydrogels (PL) containing the nitric oxide donor S-nitrosoglutathione (GSNO) and copper
oxide nanoparticles (CuO NPs) against melanoma cells. Individually applied NO donor or metallic
oxide nanoparticles have been widely explored against various types of cancer with encouraging
results. This is the first report to assess the potential and possible underlying mechanisms of action of
PL containing both NO donor and CuO NPs toward cancer cells. We found that PL + GSNO + CuO
NPs significantly reduced cell viability and greatly increased the levels of reactive oxygen species. In
addition, this novel platform had a huge impact on different organelles, thus triggering cell death
by inducing nuclear changes, a loss of mitochondrial membrane potential, and lipid peroxidation.
Thus, GSNO and CuO NPs incorporated into PL hydrogels might find important applications in the
treatment of skin cancer.
Como referenciar
CABRAL, FERNANDA V.; SANTANA, BIANCA de M.; LANGE, CAMILA N.; BATISTA, BRUNO L.; SEABRA, AMEDEA B.; RIBEIRO, MARTHA S. Pluronic F-127 hydrogels containing copper oxide nanoparticles and a nitric oxide donor to treat skin cancer. Pharmaceutics, v. 15, n. 1971, p. 1-19, 2023. DOI: 10.3390/ pharmaceutics15071971. Disponível em: http://repositorio.ipen.br/handle/123456789/34381. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.