Evaluating the impact of photobiomodulation therapy on Pseudomonas aeruginosa-induced acute infectious process
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2024
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ANNUAL MEETING OF THE BRAZILIAN BIOPHYSICAL SOCIETY, 48th
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Resumo
Photobiomodulation therapy (PBM) has shown potential in enhancing cellular
stimulation, promoting wound healing, and alleviating pain in healthcare settings.
However, its effects on infectious processes remain underexplored. This study aimed
to evaluate the impact of PBM on inflammation induced by Pseudomonas aeruginosa
in a mouse model. The Ethical Committee on Animal Use at IPEN approved this study.
After anesthetizing the mice, a suspension of P. aeruginosa was inoculated into their
left paws to induce infection. Six-h post-inoculation, sixteen mice were divided into two
groups: a control group (CG), which received no treatment, and a laser-treated group
(LG). The LG received PBM with a red laser (wavelength 660 nm, power 50 mW)
delivering a light dose of 3 J/cm² to the infected paw. Swelling was evaluated using
standardized photographs of the paws taken at 0, 16, and 24 h post-treatment, and
analyzed with ImageJ software. Data were analyzed using Student’s t-test, with results
considered statistically significant at p < 0.05. Results showed a significant reduction
in edema in the LG at 16 h and 24 h compared to the initial measurements. At 16 h,
the LG exhibited less swelling compared to the CG. By 24 h, edema sizes in both
groups were similar. Under the conditions of this work, our findings suggest that PBM
does not increase bacterial burden and may effectively reduce swelling in acute
infectious process. Further research is warranted to validate its potential as a strategy
for managing infectious inflammation.
Como referenciar
SILVA, ABDENEGO R.; RIBEIRO, MARTHA S. Evaluating the impact of photobiomodulation therapy on Pseudomonas aeruginosa-induced acute infectious process. In: ANNUAL MEETING OF THE BRAZILIAN BIOPHYSICAL SOCIETY, 48th, October, 2-5, 2024, São Paulo, SP. Abstract... Campinas, SP: Galoá, 2024. Disponível em: https://repositorio.ipen.br/handle/123456789/49144. Acesso em: 20 Jan 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.