Large mesopore FDU‑ 12 silica for papain encapsulation
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Journal of Porous Materials
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The usual synthesis of face-centered cubic FDU- 12 mesoporous silica reported in the literature does not mention the role
of some experimental conditions that govern its structural and textural properties. In particular, the order of introducing the
silica source into the reaction medium, the closing of the recipient setup, the concentration of the swelling agent, as well as
the more researched influence of heat treatment on the material characteristics. In this study, the results indicated that the
homogenization of F127 and TMB is essential before the introduction of TEOS into the reaction chamber to obtain a more
ordered porous structure. This, together with maintaining the nominal concentrations of all chemical compounds by properly
isolating the reaction chamber from the outside atmosphere, was crucial. The evaluation of TMB concentration revealed
that the increase of TMB resulted in increased surface area, pore volume, and size, leading to entrance pores of different
sizes, related to different amounts of TMB inside the F127 micelles. The best structural/textural results were achieved by
a hydrothermal treatment (HT) of 100 °C, while higher HT increased pores sizes, but it raised disorder. Finally, the papain
incorporation in the silica matrix preserved its catalytic properties and induced better catalytic activity, with around 42%
higher efficiency than the isolated enzyme. The evaluation of papain delivery showed rapid release within one hour, followed
by a slow, continuous release over time, finishing in 1 h.
Como referenciar
CIDES DA SILVA, L.C.; LOSITO, D.W.; PIMENTEL, D.R.O.; ANDREO FILHO, N.; MARTINS, T.S.; OTUBO, L.; SANT'ANNA, O.A.; FANTINI, M.C.A. Large mesopore FDU‑ 12 silica for papain encapsulation. Journal of Porous Materials, v. 32, p. 1717-1728, 2025. DOI: 10.1007/s10934-025-01801-1. Disponível em: https://repositorio.ipen.br/handle/123456789/49277. Acesso em: 09 Feb 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.