Photobiomodulation in the parotid and submandibular glands
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Lasers in Medical Science
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There are ongoing questions about the most effective wavelength for photobiomodulation (PBM) on major salivary glands
due to the specific anatomical location and unique optical properties of the tissues surrounding the glands. The aim of this
study was to analyze the photon propagation in the major salivary glands region of humans and rats using Monte Carlo
(MC) stochastic simulation. Phantoms were designed to replicate the tissues surrounding the parotid and submandibular
glands in humans and rats. Simulations were carried out using a MC online platform with wavelengths of 525 nm, 660 nm,
and 850 nm. An experimental assay in rats was conducted to evaluate if the wavelength with the best performance could
enhance the salivary flow. The 525 nm photons were primarily absorbed by the skin and fat tissue of humans and rats.
Only in rats, this wavelength reached the salivary glands. The 660 nm photons reached the human glands but were more
absorbed in the submandibular gland than in the parotid gland. The 850 nm photons had a higher absorption in both
human and rat parotid glands. PBM using 850 nm wavelength improved the salivary flow in rats. The 660 nm and 850 nm
wavelengths were more effectively absorbed in the human parotid and submandibular glands, respectively, compared to
the 525 nm. The increased salivary flow observed in rats following treatment with 850 nm suggests a beneficial effect of
this wavelength on salivary gland function.
Clinical trial number: Not applicable.
Como referenciar
CORREA, LUCIANA; MEIRELLES, LIS; CARNEIRO, REGINA C.G.; SILVA, FÁBIO F.A. da; WISOTZKY, ERIC L.; BERROCAL, EDOUARD. Photobiomodulation in the parotid and submandibular glands: a Monte Carlo simulation of photon penetration using 525-nm, 660-nm, and 850-nm wavelengths. Lasers in Medical Science, v. 40, p. 1-13, 2025. DOI: 10.1007/s10103-025-04507-7. Disponível em: https://repositorio.ipen.br/handle/123456789/49279. Acesso em: 09 Feb 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.