Distribution and occurrence of Leishmania infantum chagasi causing canine visceral leishmaniasis in an endemic area of Brazil
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Revista Pan-Amazônica de Saúde
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Leishmaniasis exhibits a spatial distribution strongly influenced by multiple factors. Epidemiological studies conducted
in locations close to endemic areas are mandatory to monitor disease spread. Porto Nacional, Tocantins State, Brazil,
is an endemic area for canine visceral leishmaniasis (CVL) with high transmission rates, yet few studies have examined
parasite isolation in dogs. OBJECTIVES: To determine the impact of seropositive dog euthanasia on the incidence of
human visceral leishmaniasis (HVL) cases and identify the Leishmania species circulating in dogs with CVL in Porto
Nacional from 2010 to 2019. MATERIALS AND METHODS: Seropositive dogs for CVL from Porto Nacional were
tested for parasite DNA using polymerase chain reaction (PCR) and immunohistochemistry for species characterization.
Data on animals were obtained from the local Center for Zoonosis Control, and HVL notifications (2010–2019) were
retrieved from the National Disease Notification System. RESULTS: Leishmania infantum chagasi was the only species
detected by PCR in infected dogs. The number of seropositive dogs increased over time, with the highest number in
2019. The most frequent clinical signs were lymphadenomegaly (73%), skin lesions (70%), and hepatomegaly (63%).
No positive correlation was found between euthanasia of seropositive dogs and HVL incidence. CONCLUSION: L.
infantum chagasi was confirmed in infected dogs, underscoring the need to revise and adapt control strategies to local
contexts in order to better assess the role of infected dogs in leishmaniasis endemic areas.
Como referenciar
OLIVEIRA, KLEVERSON W. de; FERREIRA, THALITA C.S.; SPENCER, PATRICK J.; OLIVEIRA JUNIOR, WALDESSE P.; FROTA, FABRICIO P.; OLIVEIRA, JAQUELINE D. de; ALMEIDA, DEBORAH B.; OTALORA, SANDRA V.; BENKO, GUILHERME; ANDRADE, DELVONEI A. de; VELIZ, MAURO J.C. Distribution and occurrence of Leishmania infantum chagasi causing canine visceral leishmaniasis in an endemic area of Brazil. Revista Pan-Amazônica de Saúde, v. 16, p. 1-11, 2025. DOI: 10.5123/S2176-6223202501671. Disponível em: https://repositorio.ipen.br/handle/123456789/49634. Acesso em: 29 Apr 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.