JOAO ALBERTO OSSO JUNIOR

JOAO ALBERTO OSSO JUNIOR

(Fonte: Lattes)

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Possui graduação em Química pela Universidade de São Paulo (1978), mestrado em Engenharia Nuclear pela Universidade Federal do Rio de Janeiro (1982) e doutorado em Ph D em Química Nuclear - University of Manchester (1986). Atualmente é pesquisador da Comissão Nacional de Energia Nuclear, revisor dos journals - Brazilian Archives of Biology and Technology, - Applied Radiation and Isotopes e professor pós-graduação da Universidade de São Paulo. Tem experiência na área de Engenharia Nuclear, com ênfase em Produção de Radioisótopos, atuando principalmente nos seguintes temas: medicina nuclear, tecnecio-99m, gerador tipo gel, reator nuclear e ciclotron. (Texto extraído do Currículo Lattes em 8 maio 2023)

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In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate
2005 - BORBOREMA, S.E.T.; ANDRADE JUNIOR, H.F.; OSSO JUNIOR, J.A.; NASCIMENTO, N.
Pentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for determination of antimony in biological systems remain complex and have low sensitivity. Radiotracer studies have a potential in pharmaceutical development. The aim of this study was to obtain a radiotracer for antimony, with suitable physical and biological properties. Meglumine antimoniate was neutron irradiated inside the IEA-R1 nuclear reactor, producing two radioisotopes 122Sb and 124Sb, with high radionuclidic purity and good specific activity. This compound showed the same antileishmanial activity as the native compound. The use of the radiotracers, easily created by neutron irradiation, could be an interesting tool to solve important questions in antimonial pharmacology.
Liquid kit for preparation of sup(188) rhenium-etidronate
2005 - MARCZEWSKI, B.; DIAS, C.R.; MORAES, V.; OSSO JUNIOR, J.A.
The aim of this study was the preparation of a liquid kit for radiolabeling of 188Re-HEDP (hydroxyethylidene diphosphonate). 188Re was obtained from alumina based 188W/ 188Re generators. This paper reports the efficacy of a cold kit stored for more than two weeks, determined by the dependence of the radiolabeling yields of 188Re-HEDP on the incubation time, reducing agent concentration, the effects of concentration of ligand, the pH of the reaction and the temperature. The cold kits showed a good stability when carrie-free rhenium-188 was added in the reaction mixture.
Study of gels of molybdenum with cerium in the preparation of generators of sup(99)Mo - sup(99m)Tc
2005 - MORAES, V.; MARCZEWSKI, B.; DIAS, C.R.; OSSO JUNIOR, J.A.
99m Tc has ideal nuclear properties for organ imaging in nuclear medicine, and it is obtained from the 99Mo99m Tc generator. Four different types of generators are available: chromatographic that uses 99Mo from fission of uranium; MEK solvent extraction; Tc2O7 sublimation; gel chromatographic. This work presents the preparation of gel generators of molybdenum with cerium and characterization of the gels: mass ratio between molybdenum and cerium, structure, size of particles and elution percentage of 99m Tc after irradiating the gels. Eight gels were prepared at the same temperature of 50 ºC with concentrations of NaOH of 2 and 4 mol/L, mass ratio of 0.31 and 0.38 and final pH of 3.5 and 4.5. The analysis of the results proved that these gels are not adequate for preparation of the generators of 99Mo99m Tc, since the elution percentages are low, when compared with the gel of molybdenum with zirconium.
Tc-sup(99m) direct radiolabeling of monoclonal antibody I or egf/r3: quality control and image studies in mice
2005 - DIAS, C.R.; MARCZEWSKI, B.; MORAES, V.; BARBOZA, M.F.; OSSO JUNIOR, J.A.
Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99mTc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99mTc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99mTc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.