Potential evaluation of mutagenic compounds 2-dodecylcyclobutanone and 2-tetradecylcyclobutanone through the Ames test
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2016
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INTERNATIONAL MEETING ON RADIATION PROCESSING, 18th
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Food irradiation is an effective and safe method for preservation and long-term storage for various applications in a wide variety of food
products. This process is performed by the use of accelerated electron beams, X-rays or gamma radiation. The 2-Alkylcyclobutanones (2-ACBs)
are the only known radiolytic products generated in foods that have fatty acids and were subjected to irradiation. In this study, the stearic and
palmitic acid was analyzed when irradiated medium 2-Tetradecylcyclobutanone (2-tDCB) and 2-Dodecylcyclobutanone (2-dDCB). Since the
1990s toxicological safety studies of 2-ACBs have been conducted extensively through synthetic compounds. Additionally, tests to determine if
the compounds have any mutagenic activity are strictly necessary. The Ames test was the test choosen for assessing the genotoxicity of both 2-
dDCB and 2tDCB compounds. It was used five different bacterial strains TA-1535, TA-1537, TA 98 and TA 100 Salmonella typhimurium, to
detect mutations in specific sites Guanine-Cytosine (GC) and WP2 uvrA, Escherichia coli was used to detect point mutations at sites of Adenine-
Thymine (AT). This research, unlike those undertaken by other authors up to now, presents some particularities in their factors for a more
complete assessment, such as the use of all necessary cell lines to identify possible mutations in specific sites, changes in solvent commonly
used, appropriate plates and the investigation of possible mutagenic effects on two important compounds 2-dDCB and 2-tDCB simultaneously.
The study revealed no mutagenic activity in any of the cell lines and concentrations evaluated. In conclusion, the compounds 2-dDCB and
2tDCB showed no mutagenic effect in concentrations detectable by the AMES test.
Como referenciar
BARBEZAN, ANGELICA B.; BISPO, ANA C.A.; MENDES, BRUNO M.; MARTINS, REGIANE; VILLAVICENCIO, ANNA L.C.H. Potential evaluation of mutagenic compounds 2-dodecylcyclobutanone and 2-tetradecylcyclobutanone through the Ames test. In: INTERNATIONAL MEETING ON RADIATION PROCESSING, 18th, November 07-11, 2016, Vancouver, BC, Canada. Abstract... Disponível em: http://repositorio.ipen.br/handle/123456789/27461. Acesso em: 27 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.