Antimicrobial photodynamic therapy can be an effective adjuvant for surgical wound healing in cattle
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Photodiagnosis and Photodynamic Therapy
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Background Rumenostomy is a useful procedure commonly performed in cattle for medical treatment of domestic ruminants with forestomach diseases. Methylene blue (MB)-mediated antimicrobial photodynamic therapy (APDT) has been broadly investigated to treat infected wounds. Aim The aim of the study was to evaluate the effectiveness of MB-mediated APDT (MB-APDT) combined with chlorhexidine and zinc oxide ointment on wound healing process after rumenostomy. Methods Fourteen Nelore bulls were subjected to rumenostomy procedure. Animals were randomly divided into MB-APDT (MB associated with a red diode laser performed immediately after surgery and repeated on days 3, 5, 7 and 10) and control groups. Daily care included topical cleaning with chlorhexidine 2% followed by topical zinc oxide ointment. Animals were followed-up until the 28th day. Results Wounds presented a better post-surgical profile in MB-APDT group when it was compared with the control group. In MB-APDT group, it was also possible to observe less pain on palpation of wounds borders, less edema and inflammatory exudate. Additionally, animals from MB-APDT group were faster discharged from the cattle care facility. Conclusion Our results support the use of MB-APDT for the post-surgical management of rumenostomy. This pilot study ratifies the use of APDT in cattle and also suggests that it could be performed for other surgical procedures as a complementary approach or an alternative for topical administration of antibiotics.
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VALANDRO, PATRICIA; MASSUDA, MAYARA B.; RUSCH, ELIDIANE; BIRGEL, DANIELA B.; PEREIRA, PHILIPE P.L.; SELLERA, FABIO P.; RIBEIRO, MARTHA S.; POGLIANI, FABIO C.; BIRGEL JUNIOR, EDUARDO H. Antimicrobial photodynamic therapy can be an effective adjuvant for surgical wound healing in cattle. Photodiagnosis and Photodynamic Therapy, v. 33, p. 1-4, 2021. DOI: 10.1016/j.pdpdt.2020.102168. Disponível em: http://repositorio.ipen.br/handle/123456789/32052. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.