Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels
Carregando...
Data
2024
Data de publicação:
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Exportar
Resumo
New pharmaceutical formulations have been proposed as strategies to improve transport and provide best conditions to control the drug release rate in specific biological environments, such as mucosa surfaces. Herein, formulations containing binary systems Poloxamer (PL) 407 15 % and PL 338 15 %, combined with hyaluronic acid, carrying the local anesthetic bupivacaine (BVC), were studied by molecular dynamics, while other structural parameters were determined by Dynamic Light Scattering for stablishing relationships with mucoadhesive properties and cytotoxicity evaluation. The binary system PL 407 15 %/PL 338 15 % exhibited a well-organized structural morphology, with more hydrated corona, and increased mucoadhesive properties over mucin layers. After hyaluronic acid (HA) incorporation, it was observed an increase on the force of detachment, possibly due to HA role as a linker among mucin layers independently of PL supramolecular structures. On the other hand, the addition of BVC or HA/BVC into the binary system decreased the force of detachment, as a response of augmented of compactness of these hydrogels caused by desolvation of PO core, showing the influence of all components and their chemical interactions into the structural organization and their biopharmaceutical performance relationships.
Como referenciar
SEPULVEDA, ANDERSON F.; SILVA, JESSICA B. da; BRUSCHI, MARCOS L.; FRANCO, MARGARETH K.K.D.; YOKAICHIYA, FABIANO; TOFOLI, GIOVANA R.; CEREDA, CINTIA M.S.; ROSSO, ANABELLA P.; GIACOMELLI, FERNANDO C.; SCOTT, ANA L.; ARAUJO, DANIELE R. de. Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels: from molecular modelling to biointerfaces interactions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 698, p. 1-13, 2024. DOI: 10.1016/j.colsurfa.2024.134527. Disponível em: https://repositorio.ipen.br/handle/123456789/48792. Acesso em: 17 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.