Antimicrobial photodynamic therapy with methylene blue and its derivatives in animal studies
Carregando...
Data
Data de publicação
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Photodermatology Photoimmunology and Photomedicine
Exportar
Resumo
Background: Infections are complications in the wound healing process, and their treatment can lead to antibiotic overuse and bacterial resistance. Antimicrobial photodynamic therapy (aPDT) is used to treat infectious diseases caused by fungi, viruses, or bacteria. Methylene blue (MB) and its derivatives are commonly used dyes in antimicrobial photodynamic therapy (aPDT–MB). Methods: This study is a PRISMA systematic review of animal models used to discuss the usefulness and therapeutic parameters of aPDT–MB or its derivatives for treating infected skin wounds. Results: After an extensive literature review, 13 controlled trials totaling 261 animals were selected to evaluate skin infection by leishmaniasis and cutaneous bacterial and fungal infections. All studies found results favoring the use of aPDT–MB. Great variability in parameters was found for radiant exposure from 12 to 360 J/cm2, MB diluted in saline solution or distilled water, irradiation time from 40 to 3600 s, irradiance most commonly at a maximum of 100 mW/cm2, and wavelength used mainly in the 630–670 nm range. Conclusion: MB is a safe and promising agent used as a photosensitizer in aPDT for skin-infected lesions. There is great variability in the parameters found. Comparisons concerning concentration, irradiation time, and light intensity need to be performed.
Como referenciar
CARDOZO, ANA P.M.; SILVA, DANIELA de F.T. da; FERNANDES, KRISTIANNE P.S.; FERREIRA, RITA de C.; LINO-DOS-SANTOS-FRANCO, ADRIANA; RODRIGUES, MARIA F.S.D.; MOTTA, LARA J.; CECATTO, REBECA B. Antimicrobial photodynamic therapy with methylene blue and its derivatives in animal studies: systematic review. Photodermatology Photoimmunology and Photomedicine, v. 40, n. 4, p. 1-14, 2024. DOI: 10.1111/phpp.12978. Disponível em: https://repositorio.ipen.br/handle/123456789/48848. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.