Incidence of adverse events related to therapies with sodium iodine (131I)
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Brazilian Journal of Radiation Sciences
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Radiopharmaceuticals for therapeutic have been increasingly used for the
treatment of various pathologies. Beta-emitting radionuclides stand out in this modality
due to the physical characteristics of the emitted particle. Iodine-131 (131I) is an example
of a beta-emitting radionuclide, applied in the production of radiopharmaceuticals such
as sodium iodine (131I), which represents an excellent therapeutic modality in the treatment
of differentiated thyroid carcinomas. As well as other therapeutic modalities, radionuclide
therapy using radiopharmaceuticals can also cause adverse reactions. This study aimed to
evaluate the incidence of possible adverse events related to therapy with sodium iodine
(131I), and evaluate the correlation with the administered activities, obtaining
unprecedented pharmacovigilance data related to the use of therapeutic
radiopharmaceuticals in Brazil. A retrospective analysis of medical records was carried out
with electronic patients’ data diagnosed with differentiated thyroid carcinoma and
undergoing therapy with radioiodine. A total of 116 patients were recovered from
January/2019 to April/2021 and 89 were included according to the inclusion criteria. Of
the patients, 54.6% reported an adverse event after radioiodine therapy. The most
frequent events were those related to the gastrointestinal tract and local irradiation, and it
was possible to identify that there was an increased incidence of events in those patients
who were treated with greater activities. Based on the results obtained, the present study
demonstrated the presence of acute events related to therapy in the studied population
and that the incidence of events was correlated with the activity prescribed.
Como referenciar
FERNANDES, J.C.; ARAUJO, E.B.; JOAQUIM, A.I. Incidence of adverse events related to therapies with sodium iodine (131I): contribution to the pharmacovigilance in Brazil. Brazilian Journal of Radiation Sciences, v. 12, n. 3, p. 1-16, 2024. DOI: 10.15392/2319-0612.2024.2481. Disponível em: https://repositorio.ipen.br/handle/123456789/49057. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.