Porphyrin-coated gold nanoparticles associated with radiotherapy in the treatment of triple-negative breast cancer
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2024
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ANNUAL MEETING OF THE BRAZILIAN BIOPHYSICAL SOCIETY, 48th
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Resumo
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that accounts for
around 20% of all invasive breast cancers and is characterized by resistance to
conventional treatments, such as radiotherapy (RT). Photodynamic therapy (PDT)
using porphyrins has been described in the literature as a potential therapy against
cancer. With advancements in nanomedicine, nanoparticles (NPs) are now being used
to deliver the photosensitizer with greater precision and improve the effects of RT. Our
goal in this work was to develop an NP coated with porphyrin and combine it with RT
in the treatment of TNBC. MDA-MB-231 cells were subjected to PDT using a
porphyrin-coated NP and a red light (660 ± 11 nm, 40 J.cm-2). Immediately after PDT,
the cells were exposed to RT with a dose of 2 Gy. Reactive oxygen species (ROS)
and antioxidant defenses were evaluated, as well as cell viability over time for both
monolayer and spheroid cultures. Our results showed that the NPs coated with TMPyP
had good stability, high absorption in the red region, and reduced levels of thioredoxin
reductase. Furthermore, when the therapies were combined, cell survival decreased
over time and ROS levels increased. Thus, our results suggest that the combination
of PDT using porphyrin-coated gold nanoparticles and radiotherapy has significant
potential and could be an effective strategy in the treatment of TNBC.
Como referenciar
SILVA, CAMILA R.; RIBEIRO, MARTHA S.; HEUSKIN, ANNE-CATHERINE. Porphyrin-coated gold nanoparticles associated with radiotherapy in the treatment of triple-negative breast cancer. In: ANNUAL MEETING OF THE BRAZILIAN BIOPHYSICAL SOCIETY, 48th, October, 2-5, 2024, São Paulo, SP. Abstract... Campinas, SP: Galoá, 2024. Disponível em: https://repositorio.ipen.br/handle/123456789/49146. Acesso em: 20 Jan 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.