Periódicos - Resumos

URI Permanente para esta coleçãohttps://repositorio.ipen.br/handle/123456789/8748

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Agora exibindo 1 - 20 de 439

Validation of thin layer chromatography (TLC) for radiochemical impurity determination of 68Ga-PSMA-11
2026 - BALIEIRO, LUIZA M.; SILVA, LAILA L. da; FREIRE, MARIA R. B.; PEREIRA, LUANA; MATTOS, RENATA R. de; SANTOS, JOEL M. dos; MATSUDA, MARGARETH M. N.; ARAUJO, ELAINE B. de
Prospects for the production of therapeutic radioisotopes based on installed capacity in Argentina and Brazil
2026 - MARQUES, FABIO L. N.; POZZI, EMILIANO; BULARTE, ANA C. L.; POZZI, OSCAR; GENEZINI, FREDERICO A.; BERNARDES, EMERSON; COSTA, ISOLDA
Polypharmacy and potential drug–drug interactions with novel androgen receptor signaling inhibitors (ARSIs) in patients (pts) with high-risk non-metastatic castration-resistant prostate cancer (nmCRPC) in a real-world setting
2026 - D'SOUZA, EDWIN A.; VILLA, PAULO R.; CHIANN, CHANG; NAKANDAKARE, GUILHERME K.; COSTA, RAFAEL; MUNIZ, DAVID Q. B.; FREITAS, GUILHERME F. de; HORITA, VIVIAN N.; MARTINS, JOAO C. R.; RIBEIRO-FILHO, LEOPOLDO A.; SUARTZ, CAIO; CALVO, WILSON; ARAUJO, ELAINE B. de; NAHAS, WILLIAM C.; MOTA, JOSE M.
Cytotoxic evaluation of a peritoneal cisplatin slow-release membrane for ovarian cancer treatment
2025 - SIMONSEN, MARCELO; KATAYAMA, MARIA; ALCANTARA, MARA; JUNQUEIRA, MARA; AGUIAR, FERNANDO; LUGAO, ADEMAR; TALIB, LEDA; ESTEVEZ-DIZ, MARIA; ANDRADE, IGOR M. de; TAYFOUR, NAJLA; MAYERHOFF, ERIC; TSUNODA, AUDREY; ANTONINI, MARCELO; SILVA, LAIS; TEIXEIRA, ANDRESSA; BARBOZA, ISABELA; SAMORA, MICHELLE; SCARANTI, MARIANA; OLIVEIRA, TAIS de; LAGINHA, PAULO; BERTOLAZZI, MARILIA; SOARES, ANDREA; FERNANDES, BRUNO; FOLGUEIRA, MARIA
Efficient computational modelling of the electronic stopping of ions with implications for proton therapy
2025 - PEREIRA, JULIO; YORIYAZ, HELIO; SHORTO, JULIAN; SANTOS, ADIMIR dos; SILVA, TIAGO F. da; TABACNIKS, MANFREDO H.; KOVAL, NATALIA; DE VERA, PABLO; GARCIA-MOLINA, RAFAEL; ABRIL, ISABEL; VOS, MAARTEN; GRANDE, PEDRO L.; MATIAS, FLAVIO
Integration of artificial intelligence and additive manufacturing in dosimetry
2024 - LEAL, D. A. U.; SILVA, A. C. K. de S.; MEDEIROS, I. M. M. A.; BURIN, A. L.; TALACIMON, C.; SOUZA, C. D. de; ROSA, G. M.; TEODORO, L. E. H.; ANGELOCI, L. V.; RODRIGUES, P.; SGRIGNOLI, S. S.; ROSTELATO, M. E. C. M.; ZEITUNI, C. A.
This study shows the important integration of artificial intelligence and additive manufacturing systems to fabricate prototypes of LiF dosimeter packaging for cancer treatments, using FDM 3D printing technologies and PLA as raw material while considering mechanical and metallurgical requirements.
Evolution of Fricke gel dosimetry for enhanced radiotherapy quality assurance
2024 - TALACIMON, C. F.; RODRIGUES, P. S.; TEODORO, L. E. H.; BURIN, A. L.; RIGO, M. E. Z.; MEDEIROS, I. M. M. A.; SILVA, A. C. K. de S.; SGRIGNOLI, S. S.; ROSTELATO, M. E. C. M.
In summary, the advancements in Fricke Xylenol Gel dosimetry demonstrate its increasing suitability for radiotherapy applications. The proposed modifications and refined techniques for controlling oxidation and ion diffusion signify significant progress in enhancing dosimeter efficacy. These findings underscore the importance of ongoing research to optimize dosimeter performance, ensuring improved quality assurance in radiotherapy treatments.
Evaluation of the absorbed dose of a new phosphorus-32 source for brachytherapy using Monte Carlo simulation
2024 - BURIN, A. L.; SILVA, A. C. K. de S.; TALACIMON, C. F.; MEDEIROS, I. M. M. A.; TEODORO, L. E. H.; TAVARES, P. V. dos S.; RODRIGUES, P. S.; SGRIGNOLI, S. S.; SOUZA, C. D. de; ROSTELATO, M. E. C. M.
The accuracy of dose calculations is crucial for patient treatment. Simulation results are promising for optimizing dose delivery and minimizing healthy tissue exposure. This work advances accurate methods for brachytherapy applications.
Development of methodology for production of iodine-125 source for skin cancer treatment
2024 - ROSA, G. M.; LEAL, D. A. U.; SILVA, A. C. K. de S.; MEDEIROS, I. M. M. A.; TEODORO, L. E. H.; SGRIGNOLI, S. S.; ROSTELATO, M. E. C. M.; SOUZA, C. D. de
Research to develop new technologies, products and services for the treatment of malignant diseases is extremely important to improve life expectancy and bring accessible innovations that reduce side effects for those affected.
Assessment of dosimetry in oncological treatment using radioactive nanoparticles
2024 - RODRIGUES, P. S.; SILVA, A. C. K. de S.; BURIN, A. L.; TALACIMON, C. F.; ROSA, G. M.; MEDEIROS, I. M. M. A.; TEODORO, L. E. H.; ANGELOCI, L. V.; RIGO, M. E. Z.; GESSERAME, M. M. F.; SGRIGNOLI, S. S.; ZEITUNI, C. A.; ROSTELATO, M. E. C. M.
This work provides studies on the dosimetry of radioactive nanoparticles, highlighting a broad distribution of research. While the treatment shows promising viability, gaps persist, especially in describing the precise calculation of the dose in the target region, pointing to opportunities for future research to address this issue.
Revestimento de Biovidro® em implantes metálicos
2025 - SILVA, ANA C. M.; ARAUJO, MARIANA S.
Próteses metálicas são amplamente utilizadas na medicina pela alta resistência mecânica, mas apresentam limitações, como risco de infecção e rejeição. Vidros bioativos destacam-se por favorecerem a formação de hidroxiapatita (HCA) e a integração óssea, embora sua baixa resistência restrinja o uso estrutural direto. Uma alternativa é aplicá-los como revestimento em ligas metálicas, combinando robustez do metal e bioatividade do vidro. Contudo, falhas de adesão ainda são reportadas, associadas a diferenças de expansão térmica, limitações dos métodos de deposição e do preparo do substrato, entre outros. O presente estudo teve como objetivo avaliar a bioatividade e adesão do revestimento de biovidro sobre aço inoxidável 316L obtido por dip coating após imersão em solução SBF-K9.
Metodologias de durometrias de chapas finas
2025 - IAZIGI, GIOVANNI B. C.; XAVIER, MARCOS D.; COSTA, ISOLDA
A dureza de um material é a sua resistência à deformação plástica e existem alguns métodos diferentes para realizar esta medida. O método Brinell (HB) é realizado com penetrador esférico de diâmetros 10, 5 e 2,5 mm, e cargas que variam de 15,625 kgf a 3000 kgf. O método Rockwell (HR) utiliza penetrador cônico de diamante ou esférico de aço, com cargas de 15 kgf até 150 kgf. O método Vickers (HV) utiliza um penetrador piramidal e cargas de 0,010 kgf até 120 kgf. O objetivo deste trabalho é elucidar a maneira correta de realizar as medidas de dureza em chapas metálicas finas, aplicando os três métodos acima citados. A inovação aqui inclusa consiste na observância de deformações plásticas na face oposta das chapas decorrentes das indentações, fato que conduz à necessidade direta da escolha de novos parâmetros de ensaio caso venha a ocorrer. Outros dois fatores, citados pelas normas técnicas, faixa de validade das durezas e as espessuras mínimas das chapas, foram considerados.
Estudo da corrosão do AA5052-H32 após o FSW
2025 - IAZIGI, GIOVANNI B. C.; MORAIS, NATHANAEL; ARAUJO, JOAO V. de S.; COSTA, ISOLDA
O principal diferencial da técnica de soldagem por fricção e mistura (FSW) reside na capacidade de unir materiais dissimilares no estado sólido, ou seja, sem a ocorrência de fusão. No entanto, esse processo promove alterações significativas na microestrutura dos materiais envolvidos, o que pode resultar em variações na resistência à corrosão. Essas variações estão associadas à deformação dos grãos, à mistura entre os metais e à possível formação de pares galvânicos. Esta pesquisa tem como objetivo avaliar o efeito do processo FSW na resistência à corrosão da superfície da liga de alumínio AA5052-H32 (topo).
Tratamento térmico alternativo de esferoidização em aço SAE 1060
2025 - VIJAGRAN, JOAO A.V.; IAZIGI, GIOVANNI B.C.; COSTA, ISOLDA; XAVIER, MARCOS D.
Os tratamentos térmicos de esferoidização de carbonetos em aços com teores de carbono elevados (mínimo 0,5% de C) são aplicados comumente na indústria via recozimentos subcríticos, de modo a melhorar suas usinabilidades e estampabilidades[1]. A presente pesquisa tem como objetivos aplicar uma rota alternativa de esferoidização de carbonetos via beneficiamento, isto é, têmpera e revenimento [2] e compará-la com a rota convencional via recozimento subcrítico.
The importance of iodine-125 production for use in brachytherapy
2024 - MEDEIROS, I.M.M.A.; SILVA, A.C.K. de S.; BURIN, A.L.; TALACIOMON, C.F.; LEAL, D.A.U.; MOURO, J.A.; TEODORO, L.E.H.; RODRIGUES, P.S.; SILVA, R. dos S.; ROSTELATO, M.E.C.M.; ZEITUNI, C.A.
Introduction: According to the World Health Organization, 20 million new cases of cancer were reported worldwide in 2022 [1]. Iodine-125 seeds play a crucial role in a cancer treatment modality known as brachytherapy. The advantage of this treatment lies in the direct deposition of the iodine-125-containing seed into the tumor area, preserving healthy tissue. Iodine-125 is employed in the fabrication of these seeds. This radioisotope possesses low energy and a half-life of 59.4 days. Due to its characteristics, studies that facilitate the use of iodine-125 seeds are relevant, aiming to benefit a larger number of patients.
Simulation of radioactive nanoparticles in breast cancer using mcnp
2024 - SILVA, A.C.K. de S.; MEDEIROS, I.M.M.A.; BURIN, A.L.; SOUZA, C.D. de; TALACIMON, C.F.; LEAL, D.A.U.; TEODORO, L.EI.H.; ANGELOCCI, L.; RODRIGUES, P.S.; SGRIGNOLI, S.S.; ROSTELATO, M.E.C.M.; ZEITUNI, C.A.
Introduction: Brachytherapy, a treatment method for breast cancer, involves the implantation of radioactive sources within or near the tumor tissue. By integrating nanotechnology with this approach, there’s a potential to enhance treatment efficacy while reducing radiation exposure to healthy tissues. This integration entails utilizing radioactive nanoparticles (RNPs) [1]. This study aims to conduct a dose biodistribution analysis of 198AuRNPs in breast cancer using the Monte Carlo method.
Electronic stopping of protons in dna from first principles
2024 - PEREIRA, J.J.N.; HORIYAZ, H.; SHORTO, J.M.B.; SIQUEIRA, P. de T.D.; SILVA, T.F. da; TABACNIKS, M.H.; KOVAL, N.; GRANDE, P.L.; MATIAS, F.
Introduction: Ions energy-loss in targets, such as DNA, is crucial for understanding radiation effects in cancer therapy [1–3]. The quality of proton radiotherapy planning is directly influenced by accurate information on electronic stopping cross-section (SCS), emphasizing the ongoing importance of its accuracy [4]. This work aims to determine the proton’s electronic stopping in DNA using the time-dependent density functional theory (TDDFT) [5–8], combined with the Penn method [9,10], and compare it with the database [11–12]. Furthermore, the dose profile and proton range will be calculated using those electronic stopping TDDFT-Penn results on the MCNP 6.2 code [13].
Modeling alanine dose distribution for small fields in flash radiotherapy using topas
2024 - SUZART, K.; TAVARES, P.; RODRIGUES JUNIOR, O.; POTIENS, M.D.P.
Introduction: FLASH radiotherapy (FLASH-RT) is a promising approach to cancer treatment, characterized by the delivery of high doses of radiation in a short period of time, within fractions of seconds [1]. In order to demonstrate the FLASH effect, single high doses of radiation delivered in very short times through a limited number of pulses are required.
Comparing two Monte Carlo codes to simulate the ideal activity of a phosphorus-32 film source using dose rate obtained by clinical applications
2024 - TEODORO, L.E.H.; BURIN, A.L.; TAVARES, P.V. dos S.; KOKA, A.C.; TALACIMON, C.F.; RIGO, M.E.Z.; MEDEIROS, I.M.M.A.; RODRIGUES, P.S.; SGRIGNOLI, S.S.; ROSA, G.M.; ANGELOCI, L.V.; SOUZA, C.D. de; RODRIGUES JUNIOR, O.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Introduction: Phosphorus-32 encapsulated in a polymeric base is a promising source for brachytherapy, especially for intracavitary brachytherapy (IBT) [1, 2]. From the clinical studies published, a good dose rate for this source to have is 1 Gy/min [3, 4, 5]. A similar source has been developed with a new formulation. In this work, two Monte Carlo codes were compared to evaluate the ideal activity this source must have to deliver a 1 Gy/min dose rate. Materials & Methods: TOPAS 3.8 [6] and MCNP6.2 [7] were used to model two simulations, both with the source centered in the origin point, above an isotropic volume of water 1 mm deep (2.5 cm³). The source has the decay properties of phosphorus-32, whose beta emission spectrum was extracted from the IAEA website. For TOPAS, EnergyDeposit scoring was used, and tally*F8 for MCNP. Dividing dose per decay by the dose rate of 1 Gy/min, the simulated source’s total activity can be obtained. Results: Table 1 shows the results for both simulations. Therefore, the source’s initial activity must be between 2.13 × 109 Bq (57.44 mCi) and 2.19 × 109 Bq (59.06 mCi) to obtain the 1 Gy/min dose rate.With only a 2.8% difference between both codes’ results, it is safe to assume that the simulations are reliable. Summary: These results facilitate the source manufacturing, and, with them, it is possible to minimize the patient’s exposure to radiation, while ensuring the quality of the treatment.
Assessment of dosimetry in oncological treatment using radioactive nanoparticles
2024 - RODRIGUES, P.S.; KOKA, A.C. de S.S.; BURIN, A.L.; TALACIMON, C.F.; ROSA, G.M.; MEDEIROS, I.M.M.A.; TEODORO, L.E.H.; ANGELOCI, L.V.; RIGO, M.E.Z.; GESSERAME, M.M.F.; SGRIGNOLI, S.S.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Introduction: With technological advances in medicine, various treatments and diagnoses have emerged, contributing to extended survival for cancer patients. In the ever-evolving landscape of nanotechnology and medicine, radioactive nanoparticles emerge as promising agents at the interface of diagnosis and therapy, offering innovative applications in the field of theranostic medicine capable of integrating both diagnosis and therapy in a single device. With this purpose, this study aims to conduct a literature review on the dosimetry of radioactive nanoparticles, intending to evaluate their feasibility for oncological treatment. Materials & Methods: The bibliographic study exclusively focuses on works related to the dosimetry of radioactive nanoparticles. The selection involved relevant topics on the Scopus platform (Elsevier), such as dosimetry, in vivo tests, and preclinical studies involving radioactive nanoparticles. Results: Out of 113 selectedworks, 51, 24, and 38 address dosimetry, in vivo tests, and preclinical studies of radioactive nanoparticles, respectively. Due to the scarcity of research, all articles were analyzed, excluding those less cited and less relevant to the objective. Most studies suggest viability as a treatment, although some do not detail the dose calculation in the target region. Summary: This work provides studies on the dosimetry of radioactive nanoparticles, highlighting a broad distribution of research. While the treatment shows promising viability, gaps persist, especially in describing the precise calculation of the dose in the target region, pointing to opportunities for future research to address this issue.

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